1350296-29-5

1350296-29-5 structure

Name: CM 764
Chemical Name: CM 764
CAS Number: 1350296-29-5
Molecular Formula: C₂₃H₂₇FN₄O₃
Molecular Weight: 426.492
Create Date: 2020-01-20 07:08:57
Modify Date: 2024-01-18 11:09:07
A potent, selective sigma-2 receptor agonist with Ki of 3.5 nM, 25-fold selectivity over sigma-1 receptors (Ki=86.6 nM); increases reduction of MTT in human SK-N-SH neuroblastoma, produces an immediate, robust, and transient increase in cytosolic calcium, consistent with sigma-2 receptor activation; increases total NAD(+)/NADH level, the ATP level, HIF1α and VEGF levelsin SK-N-SH cells.

Name	CM 764

Description	A potent, selective sigma-2 receptor agonist with Ki of 3.5 nM, 25-fold selectivity over sigma-1 receptors (Ki=86.6 nM); increases reduction of MTT in human SK-N-SH neuroblastoma, produces an immediate, robust, and transient increase in cytosolic calcium, consistent with sigma-2 receptor activation; increases total NAD(+)/NADH level, the ATP level, HIF1α and VEGF levelsin SK-N-SH cells.
References	References 1. Nicholson H, et al. J Pharmacol Exp Ther. 2016 Feb;356(2):232-43. View Related Products by Target Sigma Receptor

Molecular Formula	C₂₃H₂₇FN₄O₃
Molecular Weight	426.492