1121932-91-9
1121932-91-9 structure
- Name: CM 572
- Chemical Name: CM 572
- CAS Number: 1121932-91-9
- Molecular Formula: C22H23FN4O2S
- Molecular Weight: 426.51
- Catalog: Signaling Pathways GPCR/G Protein Sigma Receptor
- Create Date: 2020-01-12 10:49:49
- Modify Date: 2024-08-09 17:20:17
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A potent, selective, irreversible sigma-2 receptor partial agonist with Ki of 14.6 nM, >700-fold selectivity over sigma-1 receptors; induces dose-dependent cell death in SK-N-SH cells with EC50 of 7.6 uM, also demonstrates selective cytotoxic activity against PANC-1 pancreatic and MCF-7 breast cancer cell lines, with no significant effect on normal cells.
| Name | CM 572 |
|---|
| Description | A potent, selective, irreversible sigma-2 receptor partial agonist with Ki of 14.6 nM, >700-fold selectivity over sigma-1 receptors; induces dose-dependent cell death in SK-N-SH cells with EC50 of 7.6 uM, also demonstrates selective cytotoxic activity against PANC-1 pancreatic and MCF-7 breast cancer cell lines, with no significant effect on normal cells. |
|---|---|
| References | References 1. Nicholson H, et al. J Pharmacol Exp Ther. 2015 Aug;354(2):203-12. 2. Nicholson H, et al. J Pharmacol Exp Ther. 2016 Feb;356(2):232-43. View Related Products by Target Sigma Receptor |
| Molecular Formula | C22H23FN4O2S |
|---|---|
| Molecular Weight | 426.51 |