1872466-47-1

1872466-47-1 structure

Name: CM-675
Chemical Name: CM-675
CAS Number: 1872466-47-1
Molecular Formula: C₃₁H₃₂N₆O₃
Molecular Weight: 536.62
Catalog: Signaling Pathways Cell Cycle/DNA Damage HDAC
Create Date: 2019-06-30 10:26:15
Modify Date: 2024-01-08 18:08:26
CM-675 is a dual phosphodiesterase 5 (PDE5) and class I histone deacetylases-selective inhibitor, with IC50 values of 114 nM and 673 nM for PDE5 and HDAC1, respectively. CM-675 has potential to treat Alzheimer’s disease[1].

Name	CM-675

Description	CM-675 is a dual phosphodiesterase 5 (PDE5) and class I histone deacetylases-selective inhibitor, with IC50 values of 114 nM and 673 nM for PDE5 and HDAC1, respectively. CM-675 has potential to treat Alzheimer’s disease[1].
Related Catalog	Signaling Pathways >> Metabolic Enzyme/Protease >> Phosphodiesterase (PDE) Signaling Pathways >> Cell Cycle/DNA Damage >> HDAC Research Areas >> Neurological Disease Signaling Pathways >> Epigenetics >> HDAC
Target	HDAC1:673 nM (IC50, 30 min (time-dependent)) PDE5:114 nM nM (IC50)
In Vitro	CM-675 (29a) shows a significant time-dependent effect on class I HDAC inhibition, particularly towards HDAC2. For HDAC1, its inhibitory potency also increased significantly (~1 log unit) with the pre-incubation time: 673 nM (30 min), 180 nM (4 hours) and 69 nM (6 hours) [1].
References	[1]. Rabal O, et al. Discovery of in Vivo Chemical Probes for Treating Alzheimer's Disease: Dual Phosphodiesterase 5 (PDE5) and Class I Histone Deacetylase Selective Inhibitors. ACS Chem Neurosci. 2019 Mar 20;10(3):1765-1782.

Molecular Formula	C₃₁H₃₂N₆O₃
Molecular Weight	536.62