1926989-06-1

1926989-06-1 structure

Name: GNE-375
Chemical Name: GNE-375
CAS Number: 1926989-06-1
Molecular Formula: C₂₅H₂₉N₃O₅
Molecular Weight: 451.523
Catalog: Signaling Pathways Epigenetics Epigenetic Reader Domain
Create Date: 2020-01-20 10:58:56
Modify Date: 2023-01-14 18:16:17
GNE-375 is a potent, selective BRD9 inhibitor with IC50 of 5 nM, displays >480-fold selectivity over BRD4, CECR2, and TAF1; decreases BRD9 binding to chromatin, and decreases expression of ALDH1A1, a gene previously shown to be important in drug tolerance; shows remarkable potency in preventing the emergence of a drug tolerant population in EGFR mutant PC9 cells treated with EGFR inhibitors.

Name	GNE-375

Description	GNE-375 is a potent, selective BRD9 inhibitor with IC50 of 5 nM, displays >480-fold selectivity over BRD4, CECR2, and TAF1; decreases BRD9 binding to chromatin, and decreases expression of ALDH1A1, a gene previously shown to be important in drug tolerance; shows remarkable potency in preventing the emergence of a drug tolerant population in EGFR mutant PC9 cells treated with EGFR inhibitors.
References	References 1. Crawford TD, et al. Bioorg Med Chem Lett. 2017 Aug 1;27(15):3534-3541. View Related Products by Target Bromodomain

Molecular Formula	C₂₅H₂₉N₃O₅
Molecular Weight	451.523