115039-00-4
115039-00-4 structure
- Name: AhR modulator-1
- Chemical Name: AhR modulator-1
- CAS Number: 115039-00-4
- Molecular Formula: C13H7Cl3O
- Molecular Weight: 285.55
- Catalog: Signaling Pathways Immunology/Inflammation Aryl Hydrocarbon Receptor
- Create Date: 2020-04-05 18:39:05
- Modify Date: 2024-01-08 20:17:19
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AhR modulator-1 (compound 6-MCDF) is a selective and orally active aryl hydrocarbon receptor (AhR) modulator. AhR modulator-1 inhibits metastasis, in part, by inhibiting prostatic VEGF production prior to tumor formation. AhR modulator-1 also possess anti-estrogenic properties in rat uterus[1].
| Name | AhR modulator-1 |
|---|
| Description | AhR modulator-1 (compound 6-MCDF) is a selective and orally active aryl hydrocarbon receptor (AhR) modulator. AhR modulator-1 inhibits metastasis, in part, by inhibiting prostatic VEGF production prior to tumor formation. AhR modulator-1 also possess anti-estrogenic properties in rat uterus[1]. |
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| Related Catalog | |
| Target |
Aryl hydrocarbon receptor (AhR) [1][2] Prostatic VEGF[1] Estrogenic[1] |
| In Vitro | AhR modulator-1 (6-MCDF; 0.1-10 μM; 48-96 hours; ASPC-1 cells) treatment exhibits dose-dependent growth inhibitory effects with growth inhibitory effects of 26, 43 and 99% at concentrations of 0.1, 1 and 10 μM, respectively[2]. Cell Proliferation Assay[2] Cell Line: ASPC-1 cells Concentration: 0.1 μM, 1 μM and 10 μM Incubation Time: 48 hours, 72 hours, 96 hours Result: Exhibited dose-dependent growth inhibitory effects. |
| In Vivo | AhR modulator-1 (6-MCDF; 0-40 mg/kg; oral administration; daily; for 12 weeks; C57BL/6-Tg(TRAMP)8247Ng/J mice) treatment reduces the frequency of pelvic lymph node metastasis in mice fed the 40 mg/kg diet. And serum VEGF concentrations are also reduced. Prostate tumor incidence and size are not significantly reduced[1]. Animal Model: C57BL/6-Tg(TRAMP)8247Ng/J (TRAMP) mice (8-week-old)[1] Dosage: 0 mg/kg, 10 mg/kg, 40 mg/kg Administration: Oral administration; daily; for 12 weeks Result: The frequency of pelvic lymph node metastasis was reduced 5-fold in mice fed the 40 mg /kg diet.S erum VEGF concentrations were also reduced. |
| References |
| Molecular Formula | C13H7Cl3O |
|---|---|
| Molecular Weight | 285.55 |