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1616668-55-3

1616668-55-3 structure
1616668-55-3 structure
  • Name: Tetrazine-NHS ester
  • Chemical Name: Tetrazine-Ph-NHS ester
  • CAS Number: 1616668-55-3
  • Molecular Formula: C14H11N5O4
  • Molecular Weight: 313.27
  • Catalog: Signaling Pathways PROTAC PROTAC Linker
  • Create Date: 2020-06-01 19:51:03
  • Modify Date: 2024-01-04 01:21:51
  • Tetrazine-Ph-NHS ester is an alkyl/ether-based PROTAC linker that can be used in the synthesis of PROTACs[1].

Name Tetrazine-Ph-NHS ester
Synonyms MFCD29052194
Description Tetrazine-Ph-NHS ester is an alkyl/ether-based PROTAC linker that can be used in the synthesis of PROTACs[1].
Related Catalog
Target

Alkyl/ether

In Vitro PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
References

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562

Molecular Formula C14H11N5O4
Molecular Weight 313.27