Tetrazine-NHS ester

Modify Date: 2024-01-04 01:21:51

Tetrazine-NHS ester Structure
Tetrazine-NHS ester structure
Common Name Tetrazine-NHS ester
CAS Number 1616668-55-3 Molecular Weight 313.27
Density N/A Boiling Point N/A
Molecular Formula C14H11N5O4 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of Tetrazine-NHS ester


Tetrazine-Ph-NHS ester is an alkyl/ether-based PROTAC linker that can be used in the synthesis of PROTACs[1].

 Names

Name Tetrazine-Ph-NHS ester
Synonym More Synonyms

 Tetrazine-NHS ester Biological Activity

Description Tetrazine-Ph-NHS ester is an alkyl/ether-based PROTAC linker that can be used in the synthesis of PROTACs[1].
Related Catalog
Target

Alkyl/ether

In Vitro PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
References

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562

 Chemical & Physical Properties

Molecular Formula C14H11N5O4
Molecular Weight 313.27

 Synonyms

MFCD29052194
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