Shanghai Nianxing Industrial Co., Ltd
China
Product Name: LDHA-IN-3
Price:
Purity: 99.0%
Stocking Period: 10 Day
Contact: Yang

DC Chemicals Limited
China
Product Name: LDHA-IN-3
Price: ￥Inquiry/1g
Purity: 98.9%
Stocking Period: 1 Day
Contact: Tony Cao

227010-33-5

227010-33-5 structure

227010-33-5 structure

Name: LDHA-IN-3
Chemical Name: LDHA-IN-3
CAS Number: 227010-33-5
Molecular Formula: C₁₃H₉F₃Se
Molecular Weight: 301.17
Catalog: Signaling Pathways Metabolic Enzyme/Protease Lactate Dehydrogenase
Create Date: 2021-09-13 17:59:13
Modify Date: 2024-01-14 19:00:02
LDHA-IN-3, as a selenobenzene compound, is a potent, noncompetitive lactate dehydrogenase (LDHA) inhibitor (IC50=145.2 nM). LDHA-IN-3 can be used for the research of cancer[1].

Name	LDHA-IN-3

Description	LDHA-IN-3, as a selenobenzene compound, is a potent, noncompetitive lactate dehydrogenase (LDHA) inhibitor (IC50=145.2 nM). LDHA-IN-3 can be used for the research of cancer[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Metabolic Enzyme/Protease >> Lactate Dehydrogenase
Target	IC50: 145.2 nM (LDHA)[1]
In Vitro	PSTMB (0~500 μM; 48 hours; MCF-7 cells) shows cytotoxic effect[1]. PSTMB (0.01~1 μM) shows dose-dependent inhibition of LDHA activity. PSTMB (0~0.5 μM) inhibits LDHA activity in Michaelis-Menten and Lineweaver-Burk plots. PSTMB (30 and 50 μM; HT29 cells) induces ROS production and mitochondrial damage[1]. PSTMB can bind to LDHA protein efficiently. PSTMB induces the intrinsic pathway-mediated apoptosis of cancer cells via production of mitochondrial ROS[1]. Cell Viability Assay[1] Cell Line: MCF-7 cells Concentration: 0~500 μM Incubation Time: 48 hours Result: Showed cytotoxic effect.
References	[1]. Kim EY, et al. A Novel Lactate Dehydrogenase Inhibitor, 1-(Phenylseleno)-4-(Trifluoromethyl) Benzene, Suppresses Tumor Growth through Apoptotic Cell Death. Sci Rep. 2019;9(1):3969. Published 2019 Mar 8.

Molecular Formula	C₁₃H₉F₃Se
Molecular Weight	301.17