2639882-68-9

2639882-68-9 structure

Name: MAK683-CH2CH2COOH
Chemical Name: MAK683-CH2CH2COOH
CAS Number: 2639882-68-9
Molecular Formula: C₂₃H₂₁FN₆O₃
Molecular Weight: 448.45
Catalog: Signaling Pathways Epigenetics Histone Methyltransferase
Create Date: 2021-09-10 12:29:50
Modify Date: 2024-01-10 13:39:53
MAK683-CH2CH2COOH binds to EED (embryonic ectoderm development protein). MAK683-CH2CH2COOH and a VHL ligand for the E3 ubiquitin ligase have been used to design PROTAC EED degrader-1 (HY-130614) and PROTAC EED degrader-2 (HY-130615)[1].

Name	MAK683-CH2CH2COOH

Description	MAK683-CH2CH2COOH binds to EED (embryonic ectoderm development protein). MAK683-CH2CH2COOH and a VHL ligand for the E3 ubiquitin ligase have been used to design PROTAC EED degrader-1 (HY-130614) and PROTAC EED degrader-2 (HY-130615)[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Epigenetics >> Histone Methyltransferase
In Vitro	MAK683-CH2CH2COOH inhibits Karpas422 cells with a GI50 of 14 nM for 14 days treatment[1].
References	[1]. Hsu JH, et al. EED-Targeted PROTACs Degrade EED, EZH2, and SUZ12 in the PRC2 Complex. Cell Chem Biol. 2019 Nov 26. pii: S2451-9456(19)30362-9.

Molecular Formula	C₂₃H₂₁FN₆O₃
Molecular Weight	448.45

Hazard Codes	Xi