2504147-81-1

2504147-81-1 structure

Name: OM99-2 TFA
Chemical Name: OM99-2 TFA
CAS Number: 2504147-81-1
Molecular Formula: C₄₃H₆₅F₃N₈O₁₆
Molecular Weight: 1007.02
Catalog: Signaling Pathways Neuronal Signaling Beta-secretase
Create Date: 2021-11-17 10:54:56
Modify Date: 2024-01-02 09:16:14
OM99-2 TFA, an eight residue peptidomimetic, tight-binding inhibitor of human brain memapsin 2 with a Ki value of 9.58 nM[1]. OM99-2 TFA is significantly advanced the development of BACE1 inhibitor[2], has the potential for the research of the Alzheimer's disease[3].

Name	OM99-2 TFA

Description	OM99-2 TFA, an eight residue peptidomimetic, tight-binding inhibitor of human brain memapsin 2 with a Ki value of 9.58 nM[1]. OM99-2 TFA is significantly advanced the development of BACE1 inhibitor[2], has the potential for the research of the Alzheimer's disease[3].
Related Catalog	Signaling Pathways >> Neuronal Signaling >> Beta-secretase Research Areas >> Neurological Disease
Target	Ki: 9.58 nM (memapsin 2)
In Vitro	Memapsin 2 (BACE) is an aspartyl protease known as beta-secretase that acts on the production of the beta-amyloid peptide in the human brain[4].
References	[1]. Ghosh AK, et al. Design of Potent Inhibitors for Human Brain Memapsin 2 (β-Secretase). J Am Chem Soc. 2000;122(14):3522-3523. [2]. Zhao J, et al. Targeting Amyloidogenic Processing of APP in Alzheimer's Disease. Front Mol Neurosci. 2020;13:137. Published 2020 Aug 4. [3]. Dash C, et al. Aspartic peptidase inhibitors: implications in drug development. Crit Rev Biochem Mol Biol. 2003;38(2):89-119. [4]. Park H, et al. Determination of the active site protonation state of beta-secretase from molecular dynamics simulation and docking experiment: implications for structure-based inhibitor design. J Am Chem Soc. 2003;125(52):16416-16422.

Molecular Formula	C₄₃H₆₅F₃N₈O₁₆
Molecular Weight	1007.02

Hazard Codes	Xi