2754265-66-0
2754265-66-0 structure
- Name: TNIK-IN-5
- Chemical Name: TNIK-IN-5
- CAS Number: 2754265-66-0
- Molecular Formula: C22H17N3O3
- Molecular Weight: 371.39
- Catalog: Signaling Pathways Stem Cell/Wnt Wnt
- Create Date: 2022-05-21 19:13:06
- Modify Date: 2024-01-22 19:33:12
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TNIK-IN-5 is an efficient TNIK inhibitor with IC50 of 0.05 μM. TNIK-IN-5 efficiently inhibits Wnt signaling in intact cells. TNIK-IN-5 shows excellent in vitro anti-colorectal cancer activity[1].
| Name | TNIK-IN-5 |
|---|
| Description | TNIK-IN-5 is an efficient TNIK inhibitor with IC50 of 0.05 μM. TNIK-IN-5 efficiently inhibits Wnt signaling in intact cells. TNIK-IN-5 shows excellent in vitro anti-colorectal cancer activity[1]. |
|---|---|
| Related Catalog | |
| Target |
IC50: 0.05 μM (TNIK)[1] |
| In Vitro | TNIK-IN-5 (compound 8g) (1.25-5 μM; 48 hours) significantly inhibits the cell proliferation of HCT116 in a dose-dependent manner[1]. TNIK-IN-5 (1 μM; 24, 48 hours) strongly prevents HCT116 cells migration[1]. TNIK-IN-5 (10-40 μM; 48 hours) concentration-dependently inhibits the protein levels of β-catenin and TCF-4 in the nucleus, and significantly decreases the expression of Wnt target gene products, including Axin2 and c-Myc[1]. Cell Proliferation Assay Cell Line: HCT116 cells[1] Concentration: 1.25 μM, 2.5 μM, 5 μM Incubation Time: 48 hours Result: Significantly inhibited the cell proliferation in a dose-dependent manner. |
| References |
| Molecular Formula | C22H17N3O3 |
|---|---|
| Molecular Weight | 371.39 |