2470969-91-4

2470969-91-4 structure

2470969-91-4 structure

Name: SIRT1-IN-3
Chemical Name: SIRT1-IN-3
CAS Number: 2470969-91-4
Molecular Formula: C₁₃H₁₅BrN₂O
Molecular Weight: 295.18
Catalog: Signaling Pathways Cell Cycle/DNA Damage Sirtuin
Create Date: 2022-07-01 15:04:44
Modify Date: 2024-01-05 12:49:28
SIRT1-IN-3 (compound 3j) is a potent and selective SIRT1 inhibitor, with an IC50 of 4.2 μM[1].

Name	SIRT1-IN-3

Description	SIRT1-IN-3 (compound 3j) is a potent and selective SIRT1 inhibitor, with an IC50 of 4.2 μM[1].
Related Catalog	Signaling Pathways >> Epigenetics >> Sirtuin Research Areas >> Cancer Signaling Pathways >> Cell Cycle/DNA Damage >> Sirtuin
Target	SIRT1:4.2 μM (IC50) SIRT2:38 μM (IC50)
In Vitro	SIRT1-IN-3 (compound 3j) (0-100 μM, 48 h) inhibits the proliferation of human cancer cell lines including K562, HCT-116, H460, HepG2, A549, and MCF-7, and shows low cytotoxic on 293T and HUVEC[1]. Cell Cytotoxicity Assay Cell Line: Human cancer cell lines (K562, HCT-116, H460, HepG2, A549, HT-29, MCF-7) and normal cell lines (293T, HUVEC)[1] Concentration: 0, 0.01, 0.1, 1, 10, 100 μM Incubation Time: 48 h Result: Inhibited the proliferation of Human cancer cell lines including K562, HCT-116, H460, HepG2, A549, and MCF-7, with IC50 values of 47, 41, 66, 93, 52, and 64 μM, respectively. And showed low cytotoxic on 293T and HUVEC, with an IC50 values of 49 and 45 μM, respectively.
References	[1]. Laaroussi H, Ding Y, Teng Y, et al. Synthesis of indole inhibitors of silent information regulator 1 (SIRT1), and their evaluation as cytotoxic agents. Eur J Med Chem. 2020;202:112561.

Molecular Formula	C₁₃H₁₅BrN₂O
Molecular Weight	295.18