1575392-43-6
1575392-43-6 structure
- Name: Procaspase-6 inhibitor 12
- Chemical Name: Procaspase-6 inhibitor 12
- CAS Number: 1575392-43-6
- Molecular Formula: C16H13FN4O
- Molecular Weight: 296.305
- Create Date: 2022-07-02 20:49:21
- Modify Date: 2024-09-17 12:18:12
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Procaspase-6 inhibitor 12 is a small molecule, noncovalent, allosteric inhibitor of procaspase-6 with KD of 0.47 uM.Procaspase-6 inhibitor 12 binds to pro-C6 at the dimer interface and contacts amino acids Y198, T199 and E214.Procaspase-6 inhibitor 12 significantly stabilizes procaspase-6.Procaspase-6 inhibitor 12 prevents the activation of the Caspase-6 zymogen by mHTT1–586 in COS-7 cells.
| Name | Procaspase-6 inhibitor 12 |
|---|
| Description | Procaspase-6 inhibitor 12 is a small molecule, noncovalent, allosteric inhibitor of procaspase-6 with KD of 0.47 uM.Procaspase-6 inhibitor 12 binds to pro-C6 at the dimer interface and contacts amino acids Y198, T199 and E214.Procaspase-6 inhibitor 12 significantly stabilizes procaspase-6.Procaspase-6 inhibitor 12 prevents the activation of the Caspase-6 zymogen by mHTT1–586 in COS-7 cells. |
|---|---|
| References | 1. Jeremy Murray, et al. ChemMedChem. 2014 Jan;9(1):73-7, 2. 2. Ehrnhoefer DE, et al. Cell Chem Biol. 2019 Sep 19;26(9):1295-1305.e6. |
| Molecular Formula | C16H13FN4O |
|---|---|
| Molecular Weight | 296.305 |