442522-48-7
442522-48-7 structure
- Name: miR-21 inhibitor 12
- Chemical Name: miR-21 inhibitor 12
- CAS Number: 442522-48-7
- Molecular Formula: C22H17ClN2O4
- Molecular Weight: 408.838
- Create Date: 2022-07-01 22:09:12
- Modify Date: 2024-01-08 15:45:55
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miR-21 inhibitor 12 (miR-21-IN-12) is a small molecule inhibitor of microRNA-21 expression and inhibit miR-21 transcription.miR-21-IN-12 inhibited transcription of the miR-21 gene resulting in significant reductions in primary and mature miR-21 levels.miR-21-IN-12 demonstrated cytotoxicity in a cervical cancer cell line via induction of apoptosis and was capable of reducing microtumor formation in a long-term clonogenic assay.miR-21-IN-12 shows some level of selectivity for miR-21 and is not a general miRNA pathway inhibitor.
| Name | miR-21 inhibitor 12 |
|---|
| Description | miR-21 inhibitor 12 (miR-21-IN-12) is a small molecule inhibitor of microRNA-21 expression and inhibit miR-21 transcription.miR-21-IN-12 inhibited transcription of the miR-21 gene resulting in significant reductions in primary and mature miR-21 levels.miR-21-IN-12 demonstrated cytotoxicity in a cervical cancer cell line via induction of apoptosis and was capable of reducing microtumor formation in a long-term clonogenic assay.miR-21-IN-12 shows some level of selectivity for miR-21 and is not a general miRNA pathway inhibitor. |
|---|---|
| References | 1. Ankenbruck N, et al. Bioorg Med Chem. 2019 May 29. pii: S0968-0896(19)30047-1. |
| Molecular Formula | C22H17ClN2O4 |
|---|---|
| Molecular Weight | 408.838 |