miR-21 inhibitor 12

Modify Date: 2024-01-08 15:45:55

miR-21 inhibitor 12 Structure
miR-21 inhibitor 12 structure
Common Name miR-21 inhibitor 12
CAS Number 442522-48-7 Molecular Weight 408.838
Density N/A Boiling Point N/A
Molecular Formula C22H17ClN2O4 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of miR-21 inhibitor 12


miR-21 inhibitor 12 (miR-21-IN-12) is a small molecule inhibitor of microRNA-21 expression and inhibit miR-21 transcription.miR-21-IN-12 inhibited transcription of the miR-21 gene resulting in significant reductions in primary and mature miR-21 levels.miR-21-IN-12 demonstrated cytotoxicity in a cervical cancer cell line via induction of apoptosis and was capable of reducing microtumor formation in a long-term clonogenic assay.miR-21-IN-12 shows some level of selectivity for miR-21 and is not a general miRNA pathway inhibitor.

 Names

Name miR-21 inhibitor 12

 miR-21 inhibitor 12 Biological Activity

Description miR-21 inhibitor 12 (miR-21-IN-12) is a small molecule inhibitor of microRNA-21 expression and inhibit miR-21 transcription.miR-21-IN-12 inhibited transcription of the miR-21 gene resulting in significant reductions in primary and mature miR-21 levels.miR-21-IN-12 demonstrated cytotoxicity in a cervical cancer cell line via induction of apoptosis and was capable of reducing microtumor formation in a long-term clonogenic assay.miR-21-IN-12 shows some level of selectivity for miR-21 and is not a general miRNA pathway inhibitor.
References 1. Ankenbruck N, et al. Bioorg Med Chem. 2019 May 29. pii: S0968-0896(19)30047-1.

 Chemical & Physical Properties

Molecular Formula C22H17ClN2O4
Molecular Weight 408.838