miR-21 inhibitor 37

Modify Date: 2024-01-08 13:18:49

miR-21 inhibitor 37 Structure
miR-21 inhibitor 37 structure
Common Name miR-21 inhibitor 37
CAS Number 2241028-18-0 Molecular Weight 415.413
Density N/A Boiling Point N/A
Molecular Formula C21H17N7O3 Melting Point N/A
MSDS N/A Flash Point N/A

 Names

Name miR-21 inhibitor 37

 miR-21 inhibitor 37 Biological Activity

Description
In Vitro miR-21 inhibitor 37 is a novel inhibitor of miR-21 function with EC50 of 5.3 uM in HeLa-miR21-Luc assays, displays no inhibition of miR-122; miR-21 inhibitor 37 has no effect on either mature or primary miR-21 levels in HeLa cells, as well as no effect on miR-21 transcription; exhibits low micromolar potency against different established cancer cells (MCF-7 and MIA PaCa-2, IC50=4.5 and 6.7 uM); shows significant rescue of both PDCD4 (9.5-fold increase) and PTEN (1.5-fold increase) levels inA498 RCC cells, sensitizes cells to topotecan-induced apoptosis.

 Chemical & Physical Properties

Molecular Formula C21H17N7O3
Molecular Weight 415.413
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