1643806-94-3

1643806-94-3 structure

Name: BC-N102
Chemical Name: BC-N102
CAS Number: 1643806-94-3
Molecular Formula: C₁₈H₁₃ClN₂Os
Molecular Weight: 340.825
Create Date: 2022-07-29 21:15:13
Modify Date: 2024-03-26 06:17:58
BC-N102 is a first-in-class novel small molecule inhibitor for targeting oncogenic and hormonal signaling in ER-positive breast cancer.BC-N102 exhibits anticancer activity against breast cancer cell lines via interfering with cell cycle regulatory proteins and hormonal receptors signaling in vitro (IC50=0.04-10 uM), no significant activities against a normal breast cell line.BC-N102 exhibits potent antitumor activity at tolerated doses in an ER+ human xenograft breast cancer model.BC-N102 induces arrest of the cell cycle at G0/G1 phase, downregulates the expression of CDK2 and CDK4 independent of the ER in breast cancer cell lines.

Name	BC-N102

Description	BC-N102 is a first-in-class novel small molecule inhibitor for targeting oncogenic and hormonal signaling in ER-positive breast cancer.BC-N102 exhibits anticancer activity against breast cancer cell lines via interfering with cell cycle regulatory proteins and hormonal receptors signaling in vitro (IC50=0.04-10 uM), no significant activities against a normal breast cell line.BC-N102 exhibits potent antitumor activity at tolerated doses in an ER+ human xenograft breast cancer model.BC-N102 induces arrest of the cell cycle at G0/G1 phase, downregulates the expression of CDK2 and CDK4 independent of the ER in breast cancer cell lines.
References	1. Bashir Lawal, et al. Int J Biol Sci. 2021 Jul 25;17(12):3224-3238.

Molecular Formula	C₁₈H₁₃ClN₂Os
Molecular Weight	340.825