1643806-94-3
1643806-94-3 structure
- Name: BC-N102
- Chemical Name: BC-N102
- CAS Number: 1643806-94-3
- Molecular Formula: C18H13ClN2Os
- Molecular Weight: 340.825
- Create Date: 2022-07-29 21:15:13
- Modify Date: 2024-03-26 06:17:58
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BC-N102 is a first-in-class novel small molecule inhibitor for targeting oncogenic and hormonal signaling in ER-positive breast cancer.BC-N102 exhibits anticancer activity against breast cancer cell lines via interfering with cell cycle regulatory proteins and hormonal receptors signaling in vitro (IC50=0.04-10 uM), no significant activities against a normal breast cell line.BC-N102 exhibits potent antitumor activity at tolerated doses in an ER+ human xenograft breast cancer model.BC-N102 induces arrest of the cell cycle at G0/G1 phase, downregulates the expression of CDK2 and CDK4 independent of the ER in breast cancer cell lines.
| Name | BC-N102 |
|---|
| Description | BC-N102 is a first-in-class novel small molecule inhibitor for targeting oncogenic and hormonal signaling in ER-positive breast cancer.BC-N102 exhibits anticancer activity against breast cancer cell lines via interfering with cell cycle regulatory proteins and hormonal receptors signaling in vitro (IC50=0.04-10 uM), no significant activities against a normal breast cell line.BC-N102 exhibits potent antitumor activity at tolerated doses in an ER+ human xenograft breast cancer model.BC-N102 induces arrest of the cell cycle at G0/G1 phase, downregulates the expression of CDK2 and CDK4 independent of the ER in breast cancer cell lines. |
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| References | 1. Bashir Lawal, et al. Int J Biol Sci. 2021 Jul 25;17(12):3224-3238. |
| Molecular Formula | C18H13ClN2Os |
|---|---|
| Molecular Weight | 340.825 |