1507370-40-2

1507370-40-2 structure

Name: BC-1258
Chemical Name: N,N'-Bis[4-(1,3-thiazol-2-yl)benzyl]-1,2-ethanediamine
CAS Number: 1507370-40-2
Molecular Formula: C₂₂H₂₂N₄S₂
Molecular Weight: 406.567
Catalog: Signaling Pathways Apoptosis Apoptosis
Create Date: 2018-06-14 07:04:45
Modify Date: 2024-01-14 11:37:47
BC-1258, an F-box/LRR-repeat protein 2 (FBXL2) activator, can stabilize and upregulate FBXL2 levels. BC-1258 induces apoptosis of tumorigenic cells, and profoundly inhibits tumor formation in mice[1].

Name	N,N'-Bis[4-(1,3-thiazol-2-yl)benzyl]-1,2-ethanediamine
Synonyms	MFCD28137686 N,N'-Bis[4-(1,3-thiazol-2-yl)benzyl]-1,2-ethanediamine 1,2-Ethanediamine, N1,N2-bis[[4-(2-thiazolyl)phenyl]methyl]- BC-1258

Description	BC-1258, an F-box/LRR-repeat protein 2 (FBXL2) activator, can stabilize and upregulate FBXL2 levels. BC-1258 induces apoptosis of tumorigenic cells, and profoundly inhibits tumor formation in mice[1].
Related Catalog	Signaling Pathways >> Apoptosis >> Apoptosis Research Areas >> Cancer
Target	FBXL2[1]
In Vitro	BC-1258 是一种 F-box/LRR-重复蛋白 2 (FBXL2) 激活剂，可以稳定和上调 FBXL2 水平。BC-1258 诱导致瘤细胞凋亡，并显着抑制小鼠的肿瘤形成。 Cell Cycle Analysis[1] Cell Line: MLE cells Concentration: 2, 10, 50 μg/mL Incubation Time: 16 hours Result: Significantly increased the cell population within the G2/M phase. Reduced the diploid cell population and increase the numbers of polyploidal cells in a dose-dependent manner. Western Blot Analysis[1] Cell Line: U937, K562 and THP1 cells Concentration: 2, 10 μg/mL Incubation Time: 16 hours Result: Increased FBXL2 protein levels. Decreased FBXL2 substrates, including Aurora B, cyclin D2 and cyclin D3 levels.
In Vivo	BC-1258 (30 μg/mL in the drinking water) significantly reduces tumor size and weight in athymic nude mice[1].
References	[1]. Chen BB, et, al. Skp-cullin-F box E3 ligase component FBXL2 ubiquitinates Aurora B to inhibit tumorigenesis. Cell Death Dis. 2013 Aug 8;4(8):e759.

Symbol	GHS07
Signal Word	Warning
Hazard Statements	H302
RIDADR	NONH for all modes of transport