| Description |
BC-1258, an F-box/LRR-repeat protein 2 (FBXL2) activator, can stabilize and upregulate FBXL2 levels. BC-1258 induces apoptosis of tumorigenic cells, and profoundly inhibits tumor formation in mice[1].
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| Related Catalog |
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| Target |
FBXL2[1]
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| In Vitro |
BC-1258 是一种 F-box/LRR-重复蛋白 2 (FBXL2) 激活剂，可以稳定和上调 FBXL2 水平。BC-1258 诱导致瘤细胞凋亡，并显着抑制小鼠的肿瘤形成。 Cell Cycle Analysis[1] Cell Line: MLE cells Concentration: 2, 10, 50 μg/mL Incubation Time: 16 hours Result: Significantly increased the cell population within the G2/M phase. Reduced the diploid cell population and increase the numbers of polyploidal cells in a dose-dependent manner. Western Blot Analysis[1] Cell Line: U937, K562 and THP1 cells Concentration: 2, 10 μg/mL Incubation Time: 16 hours Result: Increased FBXL2 protein levels. Decreased FBXL2 substrates, including Aurora B, cyclin D2 and cyclin D3 levels.
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| In Vivo |
BC-1258 (30 μg/mL in the drinking water) significantly reduces tumor size and weight in athymic nude mice[1].
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| References |
[1]. Chen BB, et, al. Skp-cullin-F box E3 ligase component FBXL2 ubiquitinates Aurora B to inhibit tumorigenesis. Cell Death Dis. 2013 Aug 8;4(8):e759.
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