BC-1258

Modify Date: 2024-01-14 11:37:47

BC-1258 structure	Common Name	BC-1258
	CAS Number	1507370-40-2	Molecular Weight	406.567
	Density	1.2±0.1 g/cm3	Boiling Point	599.9±60.0 °C at 760 mmHg
	Molecular Formula	C₂₂H₂₂N₄S₂	Melting Point	N/A
	MSDS	Chinese USA	Flash Point	316.6±32.9 °C
	Symbol	GHS07	Signal Word	Warning

Use of BC-1258

BC-1258, an F-box/LRR-repeat protein 2 (FBXL2) activator, can stabilize and upregulate FBXL2 levels. BC-1258 induces apoptosis of tumorigenic cells, and profoundly inhibits tumor formation in mice[1].

Name	N,N'-Bis[4-(1,3-thiazol-2-yl)benzyl]-1,2-ethanediamine
Synonym	More Synonyms

Description	BC-1258, an F-box/LRR-repeat protein 2 (FBXL2) activator, can stabilize and upregulate FBXL2 levels. BC-1258 induces apoptosis of tumorigenic cells, and profoundly inhibits tumor formation in mice[1].
Related Catalog	Signaling Pathways >> Apoptosis >> Apoptosis Research Areas >> Cancer
Target	FBXL2[1]
In Vitro	BC-1258 是一种 F-box/LRR-重复蛋白 2 (FBXL2) 激活剂，可以稳定和上调 FBXL2 水平。BC-1258 诱导致瘤细胞凋亡，并显着抑制小鼠的肿瘤形成。 Cell Cycle Analysis[1] Cell Line: MLE cells Concentration: 2, 10, 50 μg/mL Incubation Time: 16 hours Result: Significantly increased the cell population within the G2/M phase. Reduced the diploid cell population and increase the numbers of polyploidal cells in a dose-dependent manner. Western Blot Analysis[1] Cell Line: U937, K562 and THP1 cells Concentration: 2, 10 μg/mL Incubation Time: 16 hours Result: Increased FBXL2 protein levels. Decreased FBXL2 substrates, including Aurora B, cyclin D2 and cyclin D3 levels.
In Vivo	BC-1258 (30 μg/mL in the drinking water) significantly reduces tumor size and weight in athymic nude mice[1].
References	[1]. Chen BB, et, al. Skp-cullin-F box E3 ligase component FBXL2 ubiquitinates Aurora B to inhibit tumorigenesis. Cell Death Dis. 2013 Aug 8;4(8):e759.

Density	1.2±0.1 g/cm3
Boiling Point	599.9±60.0 °C at 760 mmHg
Molecular Formula	C₂₂H₂₂N₄S₂
Molecular Weight	406.567
Flash Point	316.6±32.9 °C
Exact Mass	406.128601
LogP	4.90
Vapour Pressure	0.0±1.7 mmHg at 25°C
Index of Refraction	1.641

Symbol	GHS07
Signal Word	Warning
Hazard Statements	H302
RIDADR	NONH for all modes of transport

MFCD28137686

N,N'-Bis[4-(1,3-thiazol-2-yl)benzyl]-1,2-ethanediamine

1,2-Ethanediamine, N1,N2-bis[[4-(2-thiazolyl)phenyl]methyl]-

BC-1258

Shanghai Nianxing Industrial Co., Ltd
China
Product Name: BC-1258
Price: Negotiable
Purity: 98.0%
Delivery: 10 Day
Contact: Huang
Email: sales@echemcloud.com

ShangHai DC Chemicals Co.,Ltd
China
Product Name: BC-1258
Price: ￥Inquiry/1g
Purity: 98.9%
Delivery: 1 Day
Contact: Tony Lai
Email: order@dcchemicals.com

DC Chemicals Limited
China
Product Name: BC-1258
Price: ￥500.0/100mg ￥800.0/250mg ￥1600.0/1g
Purity: 98.0%
Delivery: 1 Day
Contact: Tony Cao
Email: sales@dcchemicals.com

Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: N,N′-Bis-(4-thiazol-2-yl-benzyl)-ethane-1,2-diamine
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Delivery: Inquiry
Contact: Ms Wang
Email: enquiry@dycnchem.com

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