691005-38-6
691005-38-6 structure
- Name: BC-21
- Chemical Name: BC-21
- CAS Number: 691005-38-6
- Molecular Formula: C32H36Cl2Cu2N2O2
- Molecular Weight: 680.659
- Create Date: 2020-01-12 08:56:51
- Modify Date: 2024-01-10 20:19:55
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BC-21 (NSC 109268) is a novel small molecule inhibitor that effectively inhibits the β-catenin/Tcf4 interaction with Ki of 6.55 uM; decreases the viability of β-catenin overexpressing HCT116 colon cancer cells that harbor the β-catenin mutation, and inhibits the clonogenic activity of these cells; inhibits Wnt/β-catenin signaling and down-regulates c-Myc and cyclin D1 expression in HCT116 cells.
| Name | BC-21 |
|---|
| Description | BC-21 (NSC 109268) is a novel small molecule inhibitor that effectively inhibits the β-catenin/Tcf4 interaction with Ki of 6.55 uM; decreases the viability of β-catenin overexpressing HCT116 colon cancer cells that harbor the β-catenin mutation, and inhibits the clonogenic activity of these cells; inhibits Wnt/β-catenin signaling and down-regulates c-Myc and cyclin D1 expression in HCT116 cells. |
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| References | References 1. Tian W, et al. Biochemistry. 2012 Jan 17;51(2):724-31. 2. Tian W, et al. J Biomol Screen. 2012 Apr;17(4):530-4. 3. Jain D, et al. Cancer Chemother Pharmacol. 2010 Oct;66(5):945-52. View Related Products by Target Beta-catenin |
| Molecular Formula | C32H36Cl2Cu2N2O2 |
|---|---|
| Molecular Weight | 680.659 |