2035085-19-7
2035085-19-7 structure
- Name: BC-1485
- Chemical Name: BC-1485
- CAS Number: 2035085-19-7
- Molecular Formula: C19H21N5O5S
- Molecular Weight: 431.467
- Create Date: 2020-01-19 15:53:27
- Modify Date: 2024-04-02 11:25:04
-
BC-1485 is a first-in-class, small molecule inhibitor of FIEL1 (Fibrosis-inducing E3 ligase 1) that exhibits potent activity toward disrupting FIEL1-directed PIAS4 ubiquitination; exhibits >100-fold activity in disrupting the FIEL1-PIAS4 interaction compared with BC-1480; dose-dependently increases PIAS4 protein levels, stabilize PIAS4 in cells; ameliorates fibrosis in murine models.
| Name | BC-1485 |
|---|
| Description | BC-1485 is a first-in-class, small molecule inhibitor of FIEL1 (Fibrosis-inducing E3 ligase 1) that exhibits potent activity toward disrupting FIEL1-directed PIAS4 ubiquitination; exhibits >100-fold activity in disrupting the FIEL1-PIAS4 interaction compared with BC-1480; dose-dependently increases PIAS4 protein levels, stabilize PIAS4 in cells; ameliorates fibrosis in murine models. |
|---|---|
| References | References 1. Lear T, et al. J Exp Med. 2016 May 30;213(6):1029-46. 2. Lear T, et al. Cytokine. 2016 Dec;88:193-195. View Related Products by Target E3 Ubiquitin Ligase |
| Molecular Formula | C19H21N5O5S |
|---|---|
| Molecular Weight | 431.467 |