BC-1215

Modify Date: 2024-01-11 16:04:57

BC-1215 structure	Common Name	BC-1215
	CAS Number	1507370-20-8	Molecular Weight	394.511
	Density	1.1±0.1 g/cm3	Boiling Point	589.9±50.0 °C at 760 mmHg
	Molecular Formula	C₂₆H₂₆N₄	Melting Point	N/A
	MSDS	Chinese USA	Flash Point	310.6±30.1 °C
	Symbol	GHS07	Signal Word	Warning

Use of BC-1215

BC-1215 is an inhibitor of F-box protein 3 (FBXO3, a ubiquitin E3 ligase component, IC50=0.9 μg/mL for IL-1β release). BC-1215 decreases Fbxo3-Fbxl2 interaction and prevents SCFFbxo3 catalyzed Fbxl2 ubiquitination. BC-1215 inhibits the Fbxo3-TRAF activation pathway by destabilizing TRAF1–TRAF6. BC-1215, interacts with ApaG to profoundly inhibit secretion of a broad spectrum of TH1 panel cytokines from human PBMC[1].

Name	N,N'-Bis[4-(2-pyridinyl)benzyl]-1,2-ethanediamine
Synonym	More Synonyms

Description	BC-1215 is an inhibitor of F-box protein 3 (FBXO3, a ubiquitin E3 ligase component, IC50=0.9 μg/mL for IL-1β release). BC-1215 decreases Fbxo3-Fbxl2 interaction and prevents SCFFbxo3 catalyzed Fbxl2 ubiquitination. BC-1215 inhibits the Fbxo3-TRAF activation pathway by destabilizing TRAF1–TRAF6. BC-1215, interacts with ApaG to profoundly inhibit secretion of a broad spectrum of TH1 panel cytokines from human PBMC[1].
Related Catalog	Research Areas >> Inflammation/Immunology Signaling Pathways >> PROTAC >> Ligand for E3 Ligase
References	[1]. Chen BB, et al. A combinatorial F box protein directed pathway controls TRAF adaptor stability to regulateinflammation. Nat Immunol. 2013 May;14(5):470-9.

Density	1.1±0.1 g/cm3
Boiling Point	589.9±50.0 °C at 760 mmHg
Molecular Formula	C₂₆H₂₆N₄
Molecular Weight	394.511
Flash Point	310.6±30.1 °C
Exact Mass	394.215759
LogP	3.68
Vapour Pressure	0.0±1.7 mmHg at 25°C
Index of Refraction	1.613