2484895-50-1

2484895-50-1 structure

Name: NR-160
Chemical Name: NR-160
CAS Number: 2484895-50-1
Molecular Formula: C₂₅H₂₁F₃N₆O₃
Molecular Weight: 510.477
Catalog: Signaling Pathways Cell Cycle/DNA Damage HDAC
Create Date: 2022-07-02 21:20:36
Modify Date: 2024-01-18 15:11:00
NR-160 (NR160) is a novel potent, selective inhibitor of histone deacetylase 6 (HDAC6) with IC50 of 30 nM, shows SI (75-1847 )over all HDAC class I isoforms.NR-160 induced α-tubulin acetylation (ac-α-tubulin) in treated acute myeloid leukemic (AML) cell line HL60, but not histone H3 (ac-H3) (a marker for the inhibition of class I HDACs).NR-160 enhances the cytotoxicity induction of bortezomib, epirubicin and daunorubicin on a panel of seven leukemia cell lines

Name	NR-160

Description	NR-160 (NR160) is a novel potent, selective inhibitor of histone deacetylase 6 (HDAC6) with IC50 of 30 nM, shows SI (75-1847 )over all HDAC class I isoforms.NR-160 induced α-tubulin acetylation (ac-α-tubulin) in treated acute myeloid leukemic (AML) cell line HL60, but not histone H3 (ac-H3) (a marker for the inhibition of class I HDACs).NR-160 enhances the cytotoxicity induction of bortezomib, epirubicin and daunorubicin on a panel of seven leukemia cell lines
References	1. Nina Reßing, et al. J Med Chem. 2020 Sep 24;63(18):10339-10351.

Molecular Formula	C₂₅H₂₁F₃N₆O₃
Molecular Weight	510.477