2304750-68-1

2304750-68-1 structure

Name: CXCR4 antagonist 6
Chemical Name: CXCR4 antagonist 6
CAS Number: 2304750-68-1
Molecular Formula: C₂₁H₃₀N₆
Molecular Weight: 366.50
Catalog: Signaling Pathways GPCR/G Protein CXCR
Create Date: 2022-07-02 14:04:16
Modify Date: 2024-01-07 08:38:13
CXCR4 antagonist 6 (compound 46) is a potent CXCR4 antagonist with an IC50 value of 79 nM. CXCR4 antagonist 6 inhibits CXCL12 induced cytosolic calcium flux (IC50 = 0.25 nM). CXCR4 antagonist 6 significantly mitigates CXCL12/CXCR4 mediated cell migration. CXCR4 antagonist 6 exhibits marked efficacy in a cancer metastasis model in mice[1].

Name	CXCR4 antagonist 6

Description	CXCR4 antagonist 6 (compound 46) is a potent CXCR4 antagonist with an IC50 value of 79 nM. CXCR4 antagonist 6 inhibits CXCL12 induced cytosolic calcium flux (IC50 = 0.25 nM). CXCR4 antagonist 6 significantly mitigates CXCL12/CXCR4 mediated cell migration. CXCR4 antagonist 6 exhibits marked efficacy in a cancer metastasis model in mice[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> GPCR/G Protein >> CXCR Signaling Pathways >> Immunology/Inflammation >> CXCR
Target	CXCR4:79 nM (IC50)
References	[1]. Li Z, et al. Design, synthesis, and evaluation of pyrrolidine based CXCR4 antagonists with in vivo anti-tumor metastatic activity. Eur J Med Chem. 2020;205:112537.

Molecular Formula	C₂₁H₃₀N₆
Molecular Weight	366.50