1808389-92-5

1808389-92-5 structure

Name: GABAA receptor agent 5
Chemical Name: GABAA receptor agent 5
CAS Number: 1808389-92-5
Molecular Formula: C₂₁H₂₅N₃O₂S
Molecular Weight: 383.51
Catalog: Signaling Pathways Membrane Transporter/Ion Channel GABA Receptor
Create Date: 2022-06-25 17:35:20
Modify Date: 2024-01-09 18:42:57
GABAA receptor agent 5 (compound 018) is a potent γ-GABAAR antagonist with an Ki of 0.020 µM. GABAA receptor agent 5 shows γ-GABAAR antagonist activity with low cellular membrane permeability[1].

Name	GABAA receptor agent 5

Description	GABAA receptor agent 5 (compound 018) is a potent γ-GABAAR antagonist with an Ki of 0.020 µM. GABAA receptor agent 5 shows γ-GABAAR antagonist activity with low cellular membrane permeability[1].
Related Catalog	Signaling Pathways >> Membrane Transporter/Ion Channel >> GABA Receptor Research Areas >> Neurological Disease Signaling Pathways >> Neuronal Signaling >> GABA Receptor
In Vitro	GABAA receptor agent 5 (compound 018) shows antagonist activity with IC50s of 0.24, 0.088, 0.068, 0.33, 0.79, 0.32, 0.079, 0.051 µM for α1β2δ, α4β1δ, α4β2δ, α6β2δ, α1β2γ2, α2β2γ2, α3β2γ2, α5β2γ2 subtypes, respectively[1].
References	[1]. Bavo F,et al. Structure-Activity Studies of 3,9-Diazaspiro[5.5]undecane-Based γ-Aminobutyric Acid Type A Receptor Antagonists with Immunomodulatory Effect. J Med Chem. 2021 Dec 23;64(24):17795-17812.

Molecular Formula	C₂₁H₂₅N₃O₂S
Molecular Weight	383.51