2630989-02-3

2630989-02-3 structure

Name: HDAC1/6-IN-1
Chemical Name: HDAC1/6-IN-1
CAS Number: 2630989-02-3
Molecular Formula: C₃₂H₄₅N₇O₄
Molecular Weight: 591.74
Catalog: Signaling Pathways Apoptosis Apoptosis
Create Date: 2022-07-02 16:57:08
Modify Date: 2024-01-29 00:51:24
HDAC1/6-IN-1 (compound D7) is a potent multitarget inhibitor of GLP, HDAC6 and HDAC1, with IC50 values of 1.3, 13, and 89 nM, respectively. HDAC1/6-IN-1 can inhibit the methylation and deacetylation of H3K9 on protein level. HDAC1/6-IN-1 induces cancer cell apoptosis, G0/G1 cell cycle arrest, and blocks migration and invasion[1].

Name	HDAC1/6-IN-1

Description	HDAC1/6-IN-1 (compound D7) is a potent multitarget inhibitor of GLP, HDAC6 and HDAC1, with IC50 values of 1.3, 13, and 89 nM, respectively. HDAC1/6-IN-1 can inhibit the methylation and deacetylation of H3K9 on protein level. HDAC1/6-IN-1 induces cancer cell apoptosis, G0/G1 cell cycle arrest, and blocks migration and invasion[1].
Related Catalog	Signaling Pathways >> Apoptosis >> Apoptosis Research Areas >> Cancer Signaling Pathways >> Cell Cycle/DNA Damage >> HDAC Signaling Pathways >> Epigenetics >> HDAC
Target	HDAC6:13 nM (IC50) HDAC1:89 nM (IC50)
References	[1]. Zheng H, et al. Quinazoline-based hydroxamic acid derivatives as dual histone methylation and deacetylation inhibitors for potential anticancer agents. Bioorg Med Chem. 2022 Jan 1;53:116524.

Molecular Formula	C₃₂H₄₅N₇O₄
Molecular Weight	591.74