2642394-38-3
2642394-38-3 structure
- Name: Mtb ATP synthase-IN-1
- Chemical Name: Mtb ATP synthase-IN-1
- CAS Number: 2642394-38-3
- Molecular Formula: C17H13N3O4
- Molecular Weight: 323.30
- Catalog: Signaling Pathways Anti-infection Bacterial
- Create Date: 2022-07-09 23:37:27
- Modify Date: 2024-01-12 15:08:26
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Mtb ATP synthase-IN-1 (compound 6ab) is a potent Mycobacterium tuberculosis (Mtb) ATP synthase inhibitor, with MIC of 0.452-0.499 μg/mL against Mtb. Mtb ATP synthase-IN-1 has good metabolic stability, low cytotoxicity (Vero IC50 > 64 μg/mL), and acceptable oral bioavailability. Mtb ATP synthase-IN-1 can be used for researching anti-mycobacterium[1].
| Name | Mtb ATP synthase-IN-1 |
|---|
| Description | Mtb ATP synthase-IN-1 (compound 6ab) is a potent Mycobacterium tuberculosis (Mtb) ATP synthase inhibitor, with MIC of 0.452-0.499 μg/mL against Mtb. Mtb ATP synthase-IN-1 has good metabolic stability, low cytotoxicity (Vero IC50 > 64 μg/mL), and acceptable oral bioavailability. Mtb ATP synthase-IN-1 can be used for researching anti-mycobacterium[1]. |
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| Related Catalog | |
| Target |
MIC: 0.452-0.499 μg/mL (Mtb)[1] |
| In Vivo | Mtb ATP synthase-IN-1 (50 mg/kg for PO, 5 mg/kg for IV; single dosage) exhibits good metabolic stability and acceptable oral bioavailability[1]. Pharmacokinetic Parameters of Mtb ATP synthase-IN-1 in male CD-1 mouse[1]. PO (50 mg/kg) IV (5 mg/kg) Cmax (ng/mL) 1333 1241 Tmax (h) 0.83 T1/2 (h) 0.51 0.33 AUC0-t (ng/mL·h) 2197 1667 AUC0-∞ (ng/mL·h) 2198 1672 MRT0-∞ (ng/mL) 1.36 0.28 CL (mL/min/kg) 51.4 F (%) 13.1 Animal Model: Male CD-1 mouse[1] Dosage: 50 and 5 mg/kg Administration: 50 mg/kg for PO, 5 mg/kg for IV; single dosage (Pharmacokinetics Analysis) Result: Exhibited good metabolic stability and acceptable oral bioavailability. |
| References |
| Molecular Formula | C17H13N3O4 |
|---|---|
| Molecular Weight | 323.30 |