2684412-41-5

2684412-41-5 structure

2684412-41-5 structure

Name: PI3K/AKT-IN-2
Chemical Name: PI3K/AKT-IN-2
CAS Number: 2684412-41-5
Molecular Formula: C₃₂H₂₇BrO₁₀
Molecular Weight: 651.45
Catalog: Signaling Pathways Apoptosis Apoptosis
Create Date: 2022-07-11 22:40:56
Modify Date: 2024-01-02 14:00:01
PI3K/AKT-IN-2 (Compound 12c) is a PI3K and AKT inhibitor. PI3K/AKT-IN-2 blocks the epithelial-mesenchymal transition (EMT) and induces apoptosis. PI3K/AKT-IN-2 inhibits the polymerization of tubulin[1].

Name	PI3K/AKT-IN-2

Description	PI3K/AKT-IN-2 (Compound 12c) is a PI3K and AKT inhibitor. PI3K/AKT-IN-2 blocks the epithelial-mesenchymal transition (EMT) and induces apoptosis. PI3K/AKT-IN-2 inhibits the polymerization of tubulin[1].
Related Catalog	Signaling Pathways >> Apoptosis >> Apoptosis Research Areas >> Cancer Signaling Pathways >> PI3K/Akt/mTOR >> PI3K Signaling Pathways >> Cell Cycle/DNA Damage >> Microtubule/Tubulin Signaling Pathways >> PI3K/Akt/mTOR >> Akt Signaling Pathways >> Cytoskeleton >> Microtubule/Tubulin Signaling Pathways >> Metabolic Enzyme/Protease >> MMP
Target	MMP-2
In Vitro	PI3K/AKT-IN-2 (Compound 12c) shows antiproliferative activity with IC50 values of 14.84 ± 1.53, 4.79 ± 0.71, 14.34 ± 0.57, 0.89 ± 0.023, >100 and 98.75 ± 1.59 µM against H460, MCF-7, A549, HGC-27, 293 T and GES-1 cells, respectively[1]. PI3K/AKT-IN-2 suppresses the expressions/activities of matrix metalloprotease (MMP)− 2, vimentin and up-regulation E-cadherin[1]. PI3K/AKT-IN-2 induces significant up-regulation of CDK1 proteins expression with a down-regulation of cyclin B1 and Cdc25C[1].
References	[1]. Sun W, et al. Design, semi-synthesis and bioactivity evaluation of novel podophyllotoxin derivatives as potent anti-tumor agents. Bioorg Chem. 2022 May 26;126:105906.

Molecular Formula	C₃₂H₂₇BrO₁₀
Molecular Weight	651.45