2439175-23-0
2439175-23-0 structure
- Name: c-Met/HDAC-IN-3
- Chemical Name: c-Met/HDAC-IN-3
- CAS Number: 2439175-23-0
- Molecular Formula: C34H35FN4O7
- Molecular Weight: 630.66
- Catalog: Signaling Pathways Apoptosis Apoptosis
- Create Date: 2022-08-25 08:29:07
- Modify Date: 2024-01-11 17:37:51
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c-Met/HDAC-IN-3 (Compound 15f) is a dual c-Met and HDAC inhibitor with IC50 values of 12.50 nM and 26.97 nM against c-Met and HDAC1, respectively. c-Met/HDAC-IN-3 induces apoptosis and cause cell cycle arrest in G2/M phase[1].
| Name | c-Met/HDAC-IN-3 |
|---|
| Description | c-Met/HDAC-IN-3 (Compound 15f) is a dual c-Met and HDAC inhibitor with IC50 values of 12.50 nM and 26.97 nM against c-Met and HDAC1, respectively. c-Met/HDAC-IN-3 induces apoptosis and cause cell cycle arrest in G2/M phase[1]. |
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| Related Catalog | |
| Target |
c-Met:12.50 nM (IC50) HDAC1:26.97 nM (IC50) |
| In Vitro | c-Met/HDAC-IN-3 (Compound 15f) (0-20 μM, 72 h) shows antiproliferative activities against HCT-116, MCF-7 and A549 cells[1]. c-Met/HDAC-IN-3 (0-5 μM, 48 h) induces apoptosis and arrests cell cycle at G2/M phase[1]. Cell Proliferation Assay[1] Cell Line: HCT-116, MCF-7 and A549 Concentration: 0-20 µM Incubation Time: 72 h Result: Showed antiproliferative activities with IC50 values of 0.54 ± 0.05, 0.28 ± 0.02 and 1.08 ± 0.44 μM against HCT-116, MCF-7 and A549 cells. Apoptosis Analysis[1] Cell Line: HCT-116 Concentration: 0.2, 1.0 and 5.0 µM Incubation Time: 48 h Result: Resulted in 6.97%, 7.08% and 13.21% cells apoptosis at 0.2, 1.0 and 5.0 µM, respectively. Cell Cycle Analysis[1] Cell Line: HCT-116 Concentration: 0.2, 1.0 and 5.0 µM Incubation Time: 48 h Result: Showed an obvious increase in the proportion of cells in G2/M phase in a dose-dependent manner. |
| References |
| Molecular Formula | C34H35FN4O7 |
|---|---|
| Molecular Weight | 630.66 |