2497504-81-9

2497504-81-9 structure
2497504-81-9 structure
  • Name: hCAIX-IN-11
  • Chemical Name: hCAIX-IN-11
  • CAS Number: 2497504-81-9
  • Molecular Formula: C21H15ClN4O3
  • Molecular Weight: 406.82
  • Catalog: Signaling Pathways Metabolic Enzyme/Protease Carbonic Anhydrase
  • Create Date: 2022-08-16 11:50:48
  • Modify Date: 2024-01-13 18:50:51
  • hCAIX-IN-11 (Compound 5d) is a selective carbonic anhydrase IX and XII inhibitor with Ki s of 32.7 and 623.5 nM for hCA IX and hCA XII, respectively.  hCA IX and hCA XII are transmembrane isoforms which have been characterized as biomarkers for several types of tumors. The hCA XII assists in maintenance of acid-base homoeostasis in normal as well as tumor cells[1].

Name hCAIX-IN-11
Description hCAIX-IN-11 (Compound 5d) is a selective carbonic anhydrase IX and XII inhibitor with Ki s of 32.7 and 623.5 nM for hCA IX and hCA XII, respectively.  hCA IX and hCA XII are transmembrane isoforms which have been characterized as biomarkers for several types of tumors. The hCA XII assists in maintenance of acid-base homoeostasis in normal as well as tumor cells[1].
Related Catalog
Target

Ki: 32.7 nM (hCA IX), 623.5 nM (hCA XII), >10000 nM nM (hCA I), >10000 (hCA II)[1]

References

[1]. Pavitra S Thacker,et al. Synthesis and biological evaluation of some coumarin hybrids as selective carbonic anhydrase IX and XII inhibitors. Bioorg Chem. 2020 Nov;104:104272.

Molecular Formula C21H15ClN4O3
Molecular Weight 406.82