2414921-48-3

2414921-48-3 structure

Name: PDE5/HDAC-IN-1
Chemical Name: PDE5/HDAC-IN-1
CAS Number: 2414921-48-3
Molecular Formula: C₂₇H₂₉BrN₄O₄
Molecular Weight: 553.45
Catalog: Signaling Pathways Apoptosis Apoptosis
Create Date: 2022-08-05 19:04:52
Modify Date: 2024-01-10 12:45:39
PDE5/HDAC-IN-1 (Compound 26) is a potent phosphodiesterase 5 (PDE5) and HDAC inhibitor with IC50 values of 46.3 nM and 14.5 nM, respectively. PDE5/HDAC-IN-1 induces cell apoptosis and shows anticancer activities[1].

Name	PDE5/HDAC-IN-1

Description	PDE5/HDAC-IN-1 (Compound 26) is a potent phosphodiesterase 5 (PDE5) and HDAC inhibitor with IC50 values of 46.3 nM and 14.5 nM, respectively. PDE5/HDAC-IN-1 induces cell apoptosis and shows anticancer activities[1].
Related Catalog	Signaling Pathways >> Apoptosis >> Apoptosis Research Areas >> Cancer Signaling Pathways >> Metabolic Enzyme/Protease >> Phosphodiesterase (PDE) Signaling Pathways >> Cell Cycle/DNA Damage >> HDAC Signaling Pathways >> Epigenetics >> HDAC
Target	PDE5:46.3 nM (IC50) HDAC1:2.45 μM (IC50) HDAC6:0.11 μM (IC50) HDAC8:0.12 μM (IC50)
In Vitro	PDE5/HDAC-IN-1 (Compound 26) shows growth inhibition with IC50 values of 12.35, 7.19 and 11.79 µM against HT-29, HCT-116 and SW-620 cells, respectively[1]. PDE5/HDAC-IN-1 shows cytotoxic activity with IC50 values of 1.9, 1.5, 2.5, 5.5, 9.8, 18.6, 2 and 28.2 μM against Molt 4, Sup-T1, K562, AGS, PC-3, LNCaP, T47D and CCD966SK, respectively[1].
References	[1]. ElHady AK, et al. Extending the use of tadalafil scaffold: Development of novel selective phosphodiesterase 5 inhibitors and histone deacetylase inhibitors. Bioorg Chem. 2020 May;98:103742.

Molecular Formula	C₂₇H₂₉BrN₄O₄
Molecular Weight	553.45