2633686-36-7

2633686-36-7 structure

Name: CB1R Allosteric modulator 3
Chemical Name: CB1R Allosteric modulator 3
CAS Number: 2633686-36-7
Molecular Formula: C₂₂H₁₇ClN₂O₂
Molecular Weight: 376.84
Catalog: Signaling Pathways GPCR/G Protein Cannabinoid Receptor
Create Date: 2022-08-31 12:35:46
Modify Date: 2024-07-23 18:48:28
CB1R Allosteric modulator 3, a novel analogs derived from the 2-phenylindole scaffold, is a CB1R positive allosteric modulator. CB1R Allosteric modulator 3 has potent inhibition of cAMP and β-Arrestin with EC50 values of 0.018 μM and 1.241 μM[1].

Name	CB1R Allosteric modulator 3

Description	CB1R Allosteric modulator 3, a novel analogs derived from the 2-phenylindole scaffold, is a CB1R positive allosteric modulator. CB1R Allosteric modulator 3 has potent inhibition of cAMP and β-Arrestin with EC50 values of 0.018 μM and 1.241 μM[1].
Related Catalog	Research Areas >> Neurological Disease Signaling Pathways >> GPCR/G Protein >> Cannabinoid Receptor
Target	CB1
In Vitro	CB1R Allosteric modulator 3 has potent inhibition of cAMP and β-Arrestin with EC50 values of 0.018 μM and 1.241 μM. CB1R Allosteric modulator 3 can enhance CB1R ago-PAM activity because of small lipophilic functional groups on the ortho-position of the GAT211 site-III phenyl ring[1].
References	[1]. Peter C Schaffer, et al. Focused structure-activity relationship profiling around the 2-phenylindole scaffold of a cannabinoid type-1 receptor agonist-positive allosteric modulator: site-III aromatic-ring congeners with enhanced activity and solubility. Bioorg Med Chem. 2020 Nov 1;28(21):115727.

Molecular Formula	C₂₂H₁₇ClN₂O₂
Molecular Weight	376.84