2738606-83-0
2738606-83-0 structure
- Name: A2A receptor antagonist 3
- Chemical Name: A2A receptor antagonist 3
- CAS Number: 2738606-83-0
- Molecular Formula: C26H26N6O2
- Molecular Weight: 454.52
- Catalog: Signaling Pathways GPCR/G Protein Adenosine Receptor
- Create Date: 2022-10-21 19:23:04
- Modify Date: 2024-03-19 00:59:24
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A2A receptor antagonist 3 (Example 92) is an adenosine A2a receptor antagonist with a Ki of 0.4 nM. A2A receptor antagonist 3 also binds to A2b, A1 and A3 receptor with Kis of 37, 107 and 1467 nM, respectively[1].
| Name | A2A receptor antagonist 3 |
|---|
| Description | A2A receptor antagonist 3 (Example 92) is an adenosine A2a receptor antagonist with a Ki of 0.4 nM. A2A receptor antagonist 3 also binds to A2b, A1 and A3 receptor with Kis of 37, 107 and 1467 nM, respectively[1]. |
|---|---|
| Related Catalog | |
| Target |
A2AR:0.4 nM (Ki) A2BR:37 nM (Ki) A1R:107 nM (Ki) A3R:1467 nM (Ki) |
| In Vitro | A2A receptor antagonist 3 (Example 92) (24 h) inhibits CD3/CD28 stimulated IL-2 release with an IC50 of 0.004 μM[1]. A2A receptor antagonist 3 (20 min) inhibits pCREB in CD8+T cells in human whole blood with an IC50 of 0.02 μM[1]. |
| References |
[1]. Clive Mccarthy, et al. Antagonists of the adenosine a2a receptor. Patent WO2021224636 A1. |
| Molecular Formula | C26H26N6O2 |
|---|---|
| Molecular Weight | 454.52 |