2368901-31-7
2368901-31-7 structure
- Name: BRM/BRG1 ATP Inhibitor-3
- Chemical Name: BRM/BRG1 ATP Inhibitor-3
- CAS Number: 2368901-31-7
- Molecular Formula: C26H25N5O2S2
- Molecular Weight: 503.64
- Catalog: Signaling Pathways Epigenetics Epigenetic Reader Domain
- Create Date: 2023-01-14 18:32:29
- Modify Date: 2024-01-17 11:26:39
-
BRM/BRG1 ATP Inhibitor-3 is a BRG1/BRM inhibitor. BRM/BRG1 ATP Inhibitor-3 inhibits BRM and BRG1 with IC50 values of 10.4 nM and 19.3 nM, respectively. BRM/BRG1 ATP Inhibitor-3 can be used for the research of cancers and BAF complex-related disorders[1].
| Name | BRM/BRG1 ATP Inhibitor-3 |
|---|
| Description | BRM/BRG1 ATP Inhibitor-3 is a BRG1/BRM inhibitor. BRM/BRG1 ATP Inhibitor-3 inhibits BRM and BRG1 with IC50 values of 10.4 nM and 19.3 nM, respectively. BRM/BRG1 ATP Inhibitor-3 can be used for the research of cancers and BAF complex-related disorders[1]. |
|---|---|
| Related Catalog | |
| Target |
IC50: 10.4 nM (BRM); 19.3 nM (BRG1)[1]. |
| In Vitro | BRM/BRG1 ATP Inhibitor-3 has inhibitory activity for BRM and BRG1 with IC50 values of 10.4 nM and 19.3 nM, respectively[1]. BRM/BRG1 ATP Inhibitor-3 (0.01-10 μM) has inhibition for cell proliferation in several cancer cell lines[1]. Cell Proliferation Assay[1] Cell Line: Uveal melanoma cell lines (92-1 , MP41 , MP38, MP46), prostate cancer cell lines (LNCAP), lung cancer cell lines (NCI-H1299), and immortalized embryonic kidney lines (HEK293T) Concentration: 0-10 μM Incubation Time: 3 days Result: Inhibited cell proliferation of uveal melanoma cell line 92-1 and MP41. |
| References |
[1]. Kevin J. Wilson, et al. Compounds and uses thereof. Patent. WO2021155320A1. |
| Molecular Formula | C26H25N5O2S2 |
|---|---|
| Molecular Weight | 503.64 |