2270879-17-7

2270879-17-7 structure

Name: BRM/BRG1 ATP Inhibitor-1
Chemical Name: BRM/BRG1 ATP Inhibitor-1
CAS Number: 2270879-17-7
Molecular Formula: C₁₁H₉F₃N₄O₂S
Molecular Weight: 318.27
Catalog: Research Areas Cancer
Create Date: 2019-06-30 12:37:30
Modify Date: 2024-01-10 22:06:34
BRM/BRG1 ATP Inhibitor-1 is an allosteric dual brahma homolog (BRM)/SWI/SNF related matrix associated actin dependent regulator of chromatin subfamily A member 2 (SMARCA2) and brahma related gene 1 (BRG1)/SMARCA4 ATPase activity inhibitor, both IC50s are below 0.005 µM[1].

Name	BRM/BRG1 ATP Inhibitor-1

Description	BRM/BRG1 ATP Inhibitor-1 is an allosteric dual brahma homolog (BRM)/SWI/SNF related matrix associated actin dependent regulator of chromatin subfamily A member 2 (SMARCA2) and brahma related gene 1 (BRG1)/SMARCA4 ATPase activity inhibitor, both IC50s are below 0.005 µM[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Others >> Others
Target	IC50: ﹤0.005 µM (BRM, BRG1)[1]
References	[1]. Papillon JPN, et al. Discovery of Orally Active Inhibitors of Brahma Homolog (BRM)/SMARCA2 ATPase Activity for the Treatment of Brahma Related Gene 1 (BRG1)/SMARCA4-Mutant Cancers. J Med Chem. 2018 Nov 21;61(22):10155-10172