BRM/BRG1 ATP Inhibitor-1

Modify Date: 2024-01-10 22:06:34

BRM/BRG1 ATP Inhibitor-1 Structure
BRM/BRG1 ATP Inhibitor-1 structure
Common Name BRM/BRG1 ATP Inhibitor-1
CAS Number 2270879-17-7 Molecular Weight 318.27
Density N/A Boiling Point N/A
Molecular Formula C11H9F3N4O2S Melting Point N/A
MSDS N/A Flash Point N/A

 Use of BRM/BRG1 ATP Inhibitor-1


BRM/BRG1 ATP Inhibitor-1 is an allosteric dual brahma homolog (BRM)/SWI/SNF related matrix associated actin dependent regulator of chromatin subfamily A member 2 (SMARCA2) and brahma related gene 1 (BRG1)/SMARCA4 ATPase activity inhibitor, both IC50s are below 0.005 µM[1].

 Names

Name BRM/BRG1 ATP Inhibitor-1

 BRM/BRG1 ATP Inhibitor-1 Biological Activity

Description BRM/BRG1 ATP Inhibitor-1 is an allosteric dual brahma homolog (BRM)/SWI/SNF related matrix associated actin dependent regulator of chromatin subfamily A member 2 (SMARCA2) and brahma related gene 1 (BRG1)/SMARCA4 ATPase activity inhibitor, both IC50s are below 0.005 µM[1].
Related Catalog
Target

IC50: ﹤0.005 µM (BRM, BRG1)[1]

References

[1]. Papillon JPN, et al. Discovery of Orally Active Inhibitors of Brahma Homolog (BRM)/SMARCA2 ATPase Activity for the Treatment of Brahma Related Gene 1 (BRG1)/SMARCA4-Mutant Cancers. J Med Chem. 2018 Nov 21;61(22):10155-10172

 Chemical & Physical Properties

Molecular Formula C11H9F3N4O2S
Molecular Weight 318.27
Storage condition -20°C