2758411-61-7
2758411-61-7 structure
- Name: DC-BPi-11
- Chemical Name: DC-BPi-11
- CAS Number: 2758411-61-7
- Molecular Formula: C20H23N5O2S
- Molecular Weight: 397.49
- Catalog: Signaling Pathways Epigenetics Epigenetic Reader Domain
- Create Date: 2023-03-01 12:15:42
- Modify Date: 2024-04-06 18:31:57
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DC-BPi-11 is an inhibitor of bromodomain PHD finger transcription factor (BPTF), with an IC50 value of 698 nM. DC-BPi-11 shows remarkable inhibition against leukemia cell proliferation[1].
| Name | DC-BPi-11 |
|---|
| Description | DC-BPi-11 is an inhibitor of bromodomain PHD finger transcription factor (BPTF), with an IC50 value of 698 nM. DC-BPi-11 shows remarkable inhibition against leukemia cell proliferation[1]. |
|---|---|
| Related Catalog | |
| Target |
698 nM (BPTF)[1] |
| In Vitro | DC-BPi-11 (0.1 nM-1 μM; 24 h) inhibits BPTF in human leukemia MV-4-11 cells with an EC50 value of 120 nM[1]. DC-BPi-11 (0.01 μM-100 μM; 24 h) significantly inhibits the proliferation of human leukemia MV-4-11 cells (IC50=0.89 μM), and (2.5-20 μM; 24 h) decreases downstream oncogene expression[1]. DC-BPi-11 (0.6-50 μM; 24 h) dose-dependently decreases c-Myc protein level[1]. DC-BPi-11 is safety and shows minimal effects on normal cells[1]. Western Blot Analysis[1] Cell Line: Human leukemia MV-4-11 cells Concentration: 0.6 μM, 1.8 μM, 5.6 μM, 16.6 μM, and 50 μM Incubation Time: 24 hours Result: Resulted depletion of c-Myc in a dose-dependent manner. Apoptosis Analysis[1] Cell Line: Human leukemia MV-4-11 cells Concentration: 5 μM, 10 μM, 20 μM Incubation Time: 24 hours Result: Induced cell apoptosis by arresting cell cycle at G1 phase. |
| References |
| Molecular Formula | C20H23N5O2S |
|---|---|
| Molecular Weight | 397.49 |