Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: 6H-Benzo[g]-1,3-benzodioxolo[5,6-a]quinolizine,5,8-dihydro-9,10-dimethoxy-
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483-15-8

483-15-8 structure

Name: Dihydroberberine
Chemical Name: 9,10-Dimethoxy-6,8-dihydro-5H-[1,3]dioxolo[4,5-g]isoquinolino[3,2-a]isoquinoline
CAS Number: 483-15-8
Molecular Formula: C₂₀H₁₉NO₄
Molecular Weight: 337.369
Catalog: Signaling Pathways Cell Cycle/DNA Damage HSP
Create Date: 2018-09-25 19:53:14
Modify Date: 2024-01-02 20:07:09
Dihydroberberine inhibits human ether-a-go-go-related gene (hERG) channels and remarkably reduces heat shock protein 90 (Hsp90) expression and its interaction with hERG. Dihydroberberine has anti-inflammatory, anti-atherosclerotic, hypolipidemic and antitumor activities[1].

Name	9,10-Dimethoxy-6,8-dihydro-5H-[1,3]dioxolo[4,5-g]isoquinolino[3,2-a]isoquinoline
Synonyms	9,10-Dimethoxy-5,8-dihydro-6H-[1,3]dioxolo[4,5-g]isoquinolino[3,2-a]isoquinoline Dihydroberbine 6H-1,3-Benzodioxolo[5,6-a]benzo[g]quinolizine, 5,8-dihydro-9,10-dimethoxy- 9,10-Dimethoxy-5,8-dihydro-6H-[1,3]dioxolo[4,5-g]isoquino[3,2-a]isoquinoline Dihydroberberine

Description	Dihydroberberine inhibits human ether-a-go-go-related gene (hERG) channels and remarkably reduces heat shock protein 90 (Hsp90) expression and its interaction with hERG. Dihydroberberine has anti-inflammatory, anti-atherosclerotic, hypolipidemic and antitumor activities[1].
Related Catalog	Research Areas >> Cancer Research Areas >> Cardiovascular Disease Signaling Pathways >> Metabolic Enzyme/Protease >> HSP Research Areas >> Inflammation/Immunology Signaling Pathways >> Cell Cycle/DNA Damage >> HSP Signaling Pathways >> Membrane Transporter/Ion Channel >> Potassium Channel
Target	HSP90
References	[1]. Yu D, et al. Inhibitory effects and mechanism of dihydroberberine on hERG channels expressed in HEK293 cells. PLoS One. 2017 Aug 1;12(8):e0181823.

CHEMICAL NAME :: Berbine, 13,13a-didehydro-9,10-dimethoxy-2,3-(methylenedioxy)-

TOXIC EFFECTS :: Behavioral - convulsions or effect on seizure threshold Behavioral - changes in motor activity (specific assay) Lungs, Thorax, or Respiration - respiratory stimulation

REFERENCE :: PCJOAU Pharmaceutical Chemistry Journal (English Translation). Translation of KHFZAN. (Plenum Pub. Corp., 233 Spring St., New York, NY 10013) No.1- 1967- Volume(issue)/page/year: 15,486,1981

HS Code	2934999090

HS Code	2934999090
Summary	2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%