Shanghai Nianxing Industrial Co., Ltd
China
Product Name: Berberine
Price:
Purity: 98.0%
Stocking Period: 10 Day
Contact: Yang

BioBioPha
China
Product Name: Berberine
Price: ￥Inquiry/5mg
Purity: 98.0%
Stocking Period: 10 Day
Contact: Xueping-Zheng

Shanghai Jizhi Biochemical Technology Co., Ltd
China
Product Name: Berberine
Price: ￥308.0/100mg ￥108.0/25mg ￥248.0/20mg
Purity: 98.0%
Stocking Period: Inquiry
Contact: Liu jia

Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: Berberine
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Stocking Period: Inquiry
Contact: Ms Wang

Henan Tianfu Chemical Co., Ltd.
China
Product Name: 2086-83-1 Berberine
Price: $Inquiry/1kg $Inquiry/25kg $Inquiry/1000kg $Inquiry/10ton
Purity: 99.0%
Stocking Period: Inquiry
Contact: Anson

2086-83-1

2086-83-1 structure

Name: Berberine
Chemical Name: berberine
CAS Number: 2086-83-1
Molecular Formula: C₂₀H₁₈NO₄+
Molecular Weight: 336.361
Catalog: Biochemical Chinese herbal medicine ingredients
Create Date: 2018-09-25 17:19:12
Modify Date: 2024-01-02 09:19:40
Berberine is a natural alkaline, reduces apoptosis, with potent anti-oxidative and anti-inflammatory effect[1].

Name	berberine
Synonyms	Berberine EINECS 211-195-9 5,6-Dihydro-9,10-dimethoxybenzo[g]1,3-benzodioxolo[5,6-a]quinolizinium 9,10-Dimethoxy-5,6-dihydro[1,3]dioxolo[4,5-g]isoquinolino[3,2-a]isoquinolin-7-ium 9,10-dimethoxy-5,6-dihydro[1,3]dioxolo[4,5-g]isoquino[3,2-a]isoquinolin-7-ium Berberin 1,3-Benzodioxolo[5,6-a]benzo[g]quinolizinium, 5,6-dihydro-9,10-dimethoxy- 5,6-dihydro-9,10-dimethoxy-benzo[g]-1,3-benzodioxolo[5,6-a]quinolizinium MFCD00011939 5,6-dihydro-9,10-dimethoxy-1,3-benzodioxolo[5,6-a]benzo[g]quinolizinium 7,8,13,13a-tetradehydro-9,10-dimethoxy-2,3-(methylenedioxy)berbinium Berbinium, 7,8,13,13a-tetradehydro-9,10-dimethoxy-2,3-(methylenedioxy)-

Description	Berberine is a natural alkaline, reduces apoptosis, with potent anti-oxidative and anti-inflammatory effect[1].
Related Catalog	Signaling Pathways >> Others >> Others Research Areas >> Inflammation/Immunology
References	[1]. Ma X, et al. Berberine exhibits antioxidative effects and reduces apoptosis of the vaginal epithelium in bacterial vaginosis. Exp Ther Med. 2019 Sep;18(3):2122-2130.

Melting Point	204-206ºC (dec.)
Molecular Formula	C₂₀H₁₈NO₄+
Molecular Weight	336.361
Exact Mass	336.123047
PSA	40.80000
LogP	-0.99

CHEMICAL IDENTIFICATION

RTECS NUMBER :: DR9870000

CHEMICAL NAME :: Berbinium, 7,8,13,13a-tetrahydro-9,10-dimethoxy-2,3-(methylenedi oxy)-

CAS REGISTRY NUMBER :: 2086-83-1

LAST UPDATED :: 199612

DATA ITEMS CITED :: 5

MOLECULAR FORMULA :: C20-H18-N-O4

MOLECULAR WEIGHT :: 336.39

WISWESSER LINE NOTATION :: T F5 D6 C666 GO IO ON HH&&T&&J RO1 SO1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD - Lethal dose

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: >500 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 329 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 18 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 100 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

MUTATION DATA

TYPE OF TEST :: DNA adduct

TEST SYSTEM :: Bacteria - Escherichia coli

DOSE/DURATION :: 10 umol/L

REFERENCE :: MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 89,95,1981

Hazard Codes	Xi
Safety Phrases	S24/25
RIDADR	UN 1544
WGK Germany	2
RTECS	DR9866400
Packaging Group	III
Hazard Class	6.1(b)
HS Code	2934999090

47474-50-0

2086-83-1

Literature: Natural Product Research, , vol. 28, # 7 p. 413 - 419

29074-38-2

~14%

549-21-3

2086-83-1

64939-64-6

Literature: Helvetica Chimica Acta, , vol. 85, # 4 p. 1069 - 1078

94272-86-3

~96%

2086-83-1

Literature: Hanaoka, Miyoji; Ashimori, Atsuyuki; Yasuda, Shingo Heterocycles, 1984 , vol. 22, # 10 p. 2263 - 2264

29074-38-2

2086-83-1

Literature: Tetrahedron, , vol. 56, # 49 p. 9713 - 9723

633-65-8

2086-83-1

Literature: Tetrahedron, , vol. 56, # 49 p. 9713 - 9723

113975-46-5

2086-83-1

Literature: Tetrahedron, , vol. 56, # 49 p. 9713 - 9723

94272-85-2

2086-83-1

Literature: Heterocycles, , vol. 22, # 10 p. 2263 - 2264

84229-90-3

2086-83-1

Literature: Heterocycles, , vol. 22, # 10 p. 2263 - 2264

485-91-6

2086-83-1

Literature: Natural Product Research, , vol. 28, # 7 p. 413 - 419

Precursor 5
29074-38-2 633-65-8 113975-46-5 84229-90-3
485-91-6
DownStream 8
483-15-8 3486-66-6 21796-14-5 61138-60-1
62595-72-6 549-21-3 64939-64-6 66408-27-3

HS Code	2934999090
Summary	2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

2086-83-1	84094-52-0
633-65-8	141433-60-5
29074-38-2	4263-84-7
81397-08-2	100259-65-2
316-41-6	62595-72-6
1396811-82-7	1158522-08-7
940364-43-2	1420869-98-2
134104-43-1	131615-57-1
6906-52-1	930439-75-1
1514670-34-8	1422388-83-7