1708103-76-7

1708103-76-7 structure

Name: ARTD10/PARP10-IN-1
Chemical Name: ARTD10/PARP10-IN-1
CAS Number: 1708103-76-7
Molecular Formula: C₁₂H₁₂N₂O₄
Molecular Weight: 248.23
Catalog: Signaling Pathways Cell Cycle/DNA Damage PARP
Create Date: 2023-04-02 18:11:51
Modify Date: 2024-04-05 17:40:03
ARTD10/PARP10-IN-1 (compound 23) is a potent and non-selective PARP inhibitor, targeting to mono-ADP-ribosyltransferases ARTD7/PARP15, ARTD8/PARP14, ARTD10/PARP10 and poly(ADP-ribose) polymerase-1 (ARTD1/PARP1) with IC50s of 1.7 μM, 1.6 μM, 0.8 μM, and 4.4 μM, respectively[1].

Name	ARTD10/PARP10-IN-1

Description	ARTD10/PARP10-IN-1 (compound 23) is a potent and non-selective PARP inhibitor, targeting to mono-ADP-ribosyltransferases ARTD7/PARP15, ARTD8/PARP14, ARTD10/PARP10 and poly(ADP-ribose) polymerase-1 (ARTD1/PARP1) with IC50s of 1.7 μM, 1.6 μM, 0.8 μM, and 4.4 μM, respectively[1].
Related Catalog	Signaling Pathways >> Epigenetics >> PARP Research Areas >> Inflammation/Immunology Signaling Pathways >> Cell Cycle/DNA Damage >> PARP
Target	ARTD1/PARP1:4.4 μM (IC50) ARTD10/PARP10:0.8 μM (IC50) ARTD8/PARP14:1.6 μM (IC50) ARTD7/PARP15:1.7 μM (IC50)
References	[1]. Ekblad T, et al. Towards small molecule inhibitors of mono-ADP-ribosyltransferases. Eur J Med Chem. 2015 May 5;95:546-51.

Molecular Formula	C₁₂H₁₂N₂O₄
Molecular Weight	248.23