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1049741-55-0

1049741-55-0 structure
1049741-55-0 structure
  • Name: Cardiogenol C (hydrochloride)
  • Chemical Name: 2-({2-[(4-Methoxyphenyl)amino]-4-pyrimidinyl}amino)ethanol hydroc hloride (1:1)
  • CAS Number: 1049741-55-0
  • Molecular Formula: C13H17ClN4O2
  • Molecular Weight: 296.75300
  • Catalog: Signaling Pathways Stem Cell/Wnt Wnt
  • Create Date: 2016-03-16 06:26:19
  • Modify Date: 2024-01-12 16:38:54
  • Cardiogenol C hydrochloride is a cell-permeable pyrimidine compound which potently induces the differentiation of ESCs into cardiomyocytes (EC50= 100 nM).IC50 value: 100 nM (EC50)Target:in vitro: Cardiogenol C hydrochloride is a cardiomyogenesis inducer in embryonic stem cells. Cardiogenol C induces the differentiation of myosin heavy chain-positive cardiomyocytes from embryonic stem cells with an EC50 value of 0.1 μM; about 90% of embryonic stem cells treated with 0.25 μM of Cardiogenol C express the cardiac muscle cell specific transcription factors GATA-4, MEF2, and Nkx2.5 and display the characteristic beating behavior of differentiated cardiomyocytes. Cardiogenol C (a diaminopyrimidine) induces cardiac differentiation in P19 and in P19Cl6 cells. [1] Cardiogenol C could activate Wnt/β-catenin signaling to induce cardiogenesis. Cardiogenol C-treatment significantly decreased HBPCs proliferation. Cardiogenol C was able to induce HBPCs to transdifferentiate into cardiomyocyte-like cells.[2]

Name 2-({2-[(4-Methoxyphenyl)amino]-4-pyrimidinyl}amino)ethanol hydroc hloride (1:1)
Synonyms Combretastatin A4
Cardiogenol C,Hydrochloride
Cardiogenol C (hydrochloride)
Description Cardiogenol C hydrochloride is a cell-permeable pyrimidine compound which potently induces the differentiation of ESCs into cardiomyocytes (EC50= 100 nM).IC50 value: 100 nM (EC50)Target:in vitro: Cardiogenol C hydrochloride is a cardiomyogenesis inducer in embryonic stem cells. Cardiogenol C induces the differentiation of myosin heavy chain-positive cardiomyocytes from embryonic stem cells with an EC50 value of 0.1 μM; about 90% of embryonic stem cells treated with 0.25 μM of Cardiogenol C express the cardiac muscle cell specific transcription factors GATA-4, MEF2, and Nkx2.5 and display the characteristic beating behavior of differentiated cardiomyocytes. Cardiogenol C (a diaminopyrimidine) induces cardiac differentiation in P19 and in P19Cl6 cells. [1] Cardiogenol C could activate Wnt/β-catenin signaling to induce cardiogenesis. Cardiogenol C-treatment significantly decreased HBPCs proliferation. Cardiogenol C was able to induce HBPCs to transdifferentiate into cardiomyocyte-like cells.[2]
Related Catalog
References

[1]. Jasmin, et al. Chemical induction of cardiac differentiation in p19 embryonal carcinoma stem cells. Stem Cells Dev. 2010 Mar;19(3):403-412.

[2]. Yau WW, et al. Cardiogenol C can induce Mouse Hair Bulge Progenitor Cells to Transdifferentiate into Cardiomyocyte-like Cells. Proteome Sci. 2011 Jan 19;9(1):3.

Molecular Formula C13H17ClN4O2
Molecular Weight 296.75300
Exact Mass 296.10400
PSA 82.53000
LogP 1.92990
Storage condition -20℃