671225-39-1

671225-39-1 structure

Name: Cardiogenol C
Chemical Name: Cardiogenol C hydrochloride
CAS Number: 671225-39-1
Molecular Formula: C₁₃H₁₆N₄O₂
Molecular Weight: 296.753
Catalog: Signaling Pathways Stem Cell/Wnt Wnt
Create Date: 2018-06-13 07:37:11
Modify Date: 2024-01-02 07:22:49
Cardiogenol C is a potent cell-permeable pyrimidine inducer which prompts the differentiation of ESCs into cardiomyocytes (EC50=100 nM)[1]. Cardiogenol C also acts cardiomyogenic on already lineage-committed progenitor cell types with a limited degree of plasticity. Cardiogenol C is a useful cardiomyogenic agent and can be used as a tool to improve cardiac repair by cell transplantation therapy in animal models[2].

Name	Cardiogenol C hydrochloride
Synonyms	Ethanol, 2-[[2-[(4-methoxyphenyl)amino]-4-pyrimidinyl]amino]-, hydrochloride (1:1) 2-({2-[(4-Methoxyphenyl)amino]pyrimidin-4-yl}amino)ethanol hydrochloride (1:1) 2-({2-[(4-Methoxyphenyl)amino]-4-pyrimidinyl}amino)ethanol hydrochloride (1:1)

Description	Cardiogenol C is a potent cell-permeable pyrimidine inducer which prompts the differentiation of ESCs into cardiomyocytes (EC50=100 nM)[1]. Cardiogenol C also acts cardiomyogenic on already lineage-committed progenitor cell types with a limited degree of plasticity. Cardiogenol C is a useful cardiomyogenic agent and can be used as a tool to improve cardiac repair by cell transplantation therapy in animal models[2].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Stem Cell/Wnt >> Wnt
Target	EC50: 100 nM (differentiation of ESCs into cardiomyocytes)[1]
In Vitro	Cardiogenol C (1 μM; 7 days) has a cardiomyogenic effect on P19 cells, it significantly increases atrial natriuretic factor (ANF, nppa) in P19 cells when it compares to untreated control cells[1]. Cardiogenol C (0.01-100 μM; 7 days) significantly increases ANF expression. In addition, another frequently used cardiac marker gene (NKX2-5) is also significantly increased by this small molecule in C2C12 cells[2]. Cardiogenol C (0.001-100 μM; 7 days) increases cardiac Nav1.5 sodium channel protein expression as dose-dependent manner in C2C12 cells[2]. Cardiogenol C (0.01-100 μM; 7 days) does not effect cell growth even at 10 μM. In addition, Cardiogenol C either solves in water or DMSO generates a similar effect. The highest concentration, 100 μM has significant cellular toxicity on C2C12 cells[2]. RT-PCR[2] Cell Line: C2C12 cells Concentration: 0.01 μM; 0.1 μM; 1 μM; 3 μM; 10 μM; 30 μM; 100 μM Incubation Time: 7 days Result: Increases ANF and NKX2.5 mRNA level as a dose-dependent manner. Western Blot Analysis[2] Cell Line: C2C12 cells Concentration: 0.001 μM; 0.01 μM; 0.1 μM; 1 μM; 10 μM Incubation Time: 7 days Result: Increased cardiac Nav1.5 sodium channel protein levels. Cell Proliferation Assay[2] Cell Line: C2C12 cells Concentration: 0.01 μM; 0.1 μM; 1 μM Incubation Time: 7 days Result: Did not exert toxic effects on C2C12 cells at 0.01-10 μM treatment.
References	[1]. Wu X, et al. Small molecules that induce cardiomyogenesis in embryonic stem cells.J Am Chem Soc. 2004 Feb 18;126(6):1590-1. [2]. Mike AK, et al. Small molecule cardiogenol C upregulates cardiac markers and induces cardiac functional properties in lineage-committed progenitor cells. Cell Physiol Biochem. 2014;33(1):205-21.

Density	1.305g/cm3
Boiling Point	520.3ºC at 760 mmHg
Molecular Formula	C₁₃H₁₆N₄O₂
Molecular Weight	296.753
Flash Point	268.5ºC
Exact Mass	296.104004
PSA	79.30000
LogP	2.58100
Index of Refraction	1.667
Storage condition	-20℃

Symbol	GHS07
Signal Word	Warning
Hazard Statements	H315-H319-H335
Precautionary Statements	P261-P305 + P351 + P338
Personal Protective Equipment	dust mask type N95 (US);Eyeshields;Gloves
Hazard Codes	Xi
Risk Phrases	36/37/38
Safety Phrases	26-36
RIDADR	NONH for all modes of transport

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