1330262-09-3

1330262-09-3 structure

Name: Xipamide-d6
Chemical Name: N-[2,6-bis(trideuteriomethyl)phenyl]-4-chloro-2-hydroxy-5-sulfamoylbenzamide
CAS Number: 1330262-09-3
Molecular Formula: C₁₅H₉ClD₆N₂O₄S
Molecular Weight: 360.84600
Catalog: Research Areas Cardiovascular Disease
Create Date: 2017-04-10 16:33:06
Modify Date: 2024-01-18 12:00:43
Xipamide-d6 is the deuterium labeled Xipamide. Xipamide is a sulfonamide-based diuretic. Xipamide is an antihypertensive agent able to selectively inhibit the anion exchanger (AE)[1][2].

Name	N-[2,6-bis(trideuteriomethyl)phenyl]-4-chloro-2-hydroxy-5-sulfamoylbenzamide
Synonyms	Diurex-d6 Lumitens-d6 Xipamide-d6 Aquaphor-d6 4-Chloro-5-sulfamoyl-2',6'-salicyloxylidide-d6 Chronexan-d6

Description	Xipamide-d6 is the deuterium labeled Xipamide. Xipamide is a sulfonamide-based diuretic. Xipamide is an antihypertensive agent able to selectively inhibit the anion exchanger (AE)[1][2].
Related Catalog	Research Areas >> Cardiovascular Disease Signaling Pathways >> Others >> Others
In Vitro	Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].
References	[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. [2]. Prichard BN, et al. Xipamide. A review of its pharmacodynamic and pharmacokinetic properties and therapeutic efficacy. Drugs. 1985 Oct;30(4):313-32. [3]. Hannaert P, et al. Beneficial effects of xipamide on pH and Ca2+ ions of cardiac cells. Arch Mal Coeur Vaiss. 1990 Jul;83(8):1271-4.