179248-61-4

179248-61-4 structure

Name: EGFR/ErbB-2/ErbB-4 inhibitor-2
Chemical Name: 6,7-dimethoxy-N-(4-phenylmethoxyphenyl)quinazolin-4-amine
CAS Number: 179248-61-4
Molecular Formula: C₂₃H₂₁N₃O₃
Molecular Weight: 387.43100
Catalog: Signaling Pathways JAK/STAT Signaling EGFR
Create Date: 2016-07-11 03:04:33
Modify Date: 2024-01-11 18:23:36
EGFR/ErbB-2/ErbB-4 inhibitor-2 (Compound 5) is a EGFR and ErbB inhibitor with IC50s of 0.017 μM, 0.08 μM, 1.91 μM[1].

Name	6,7-dimethoxy-N-(4-phenylmethoxyphenyl)quinazolin-4-amine
Synonyms	HMS3229C21 4557W IN1350 EGFR/ErbB-2 Inhibitor

Description	EGFR/ErbB-2/ErbB-4 inhibitor-2 (Compound 5) is a EGFR and ErbB inhibitor with IC50s of 0.017 μM, 0.08 μM, 1.91 μM[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> JAK/STAT Signaling >> EGFR Signaling Pathways >> Protein Tyrosine Kinase/RTK >> EGFR
Target	EGFR:0.017 μM (IC50) ErbB2:0.08 μM (IC50) ErbB4:1.91 μM (IC50)
In Vitro	EGFR/ErbB-2/ErbB-4 inhibitor-2 (Compound 5) also inhibits c-Src, VEGFR2, c-Fms and with IC50s of 0.30, 2.2, and 14.0 μM, respectively[1].
References	[1]. Perry S Brignola, et al. Comparison of the biochemical and kinetic properties of the type 1 receptor tyrosine kinase intracellular domains. Demonstration of differential sensitivity to kinase inhibitors. J Biol Chem. 2002 Jan 11;277(2):1576-85.