59559-06-7

59559-06-7 structure

Name: Azido-PEG2-azide
Chemical Name: 1,8-Diazido-3,6-dioxaoctane
CAS Number: 59559-06-7
Molecular Formula: C₆H₁₂N₆O₂
Molecular Weight: 200.19800
Catalog: Signaling Pathways PROTAC PROTAC Linker
Create Date: 2016-11-18 00:14:56
Modify Date: 2024-01-10 17:00:24
Azido-PEG2-azide is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

Name	1,8-Diazido-3,6-dioxaoctane
Synonyms	1,8-Diazido-3,5-dioxaoctane bis-1,2-(2-azidoethoxy)ethane diazido triethyleneglycol 1,2-bis(2-azidoethoxy)-ethane 1-Azido-2-[2-(2-azidoethoxy)ethoxy]ethane

Description	Azido-PEG2-azide is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> PROTAC >> PROTAC Linker
Target	PEGs
In Vitro	PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
References	[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562.

19249-03-7

~10%

59559-06-7

112-26-5

~96%

59559-06-7

117013-39-5

~90%

59559-06-7

Literature: Xiao, Junpeng; Tolbert, Thomas J. Organic Letters, 2009 , vol. 11, # 18 p. 4144 - 4147

31255-10-4

~83%

59559-06-7

112-27-6

59559-06-7

Literature: Bouzide, Abderrahim; LeBerre, Nicolas; Sauve, Gilles Tetrahedron Letters, 2001 , vol. 42, # 50 p. 8781 - 8783