203805-87-2

203805-87-2 structure

Name: HEPES-d18
Chemical Name: hepes (d18)
CAS Number: 203805-87-2
Molecular Formula: C₈D₁₈N₂O₄S
Molecular Weight: 256.415
Catalog: Research Areas Others
Create Date: 2018-07-04 11:56:43
Modify Date: 2024-01-21 16:32:59
HEPES-d18 is the deuterium labeled HEPES[1]. HEPES, a nonvolatile zwitterionic chemical buffering agent, is broadly applied in cell culture. HEPES is effective at pH 6.8 to 8.2. HEPES is also a potent inducer of lysosome biogenesis[2][3][4].

Name	hepes (d18)
Synonyms	Piperazine-2,2,3,3,5,5,6,6-d-1-ethane-α,α,β,β-d-sulfonic acid-d, 4-[2-(hydroxy-d)ethyl-1,1,2,2-d]- 2-{4-[2-(H)Hydroxy(H)ethyl](H)-1-piperazinyl}(H)ethane(H)sulfonic acid 2-{4-[2-(H)Hydroxy(H)ethyl](H)piperazin-1-yl}(H)ethane(H)sulfonic acid

Description	HEPES-d18 is the deuterium labeled HEPES[1]. HEPES, a nonvolatile zwitterionic chemical buffering agent, is broadly applied in cell culture. HEPES is effective at pH 6.8 to 8.2. HEPES is also a potent inducer of lysosome biogenesis[2][3][4].
Related Catalog	Research Areas >> Others Signaling Pathways >> Others >> Others
In Vitro	Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].
References	[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216. [2]. Suzuki T, et al. Nonvolatile buffer coating of titanium to prevent its biological aging and for drug delivery. Biomaterials. 2010;31(18):4818-4828. [3]. Sledź P, et al. An experimental charge density of HEPES. Acta Crystallogr B. 201066(Pt 4):482-492. [4]. Tol MJ, et al. HEPES activates a MiT/TFE-dependent lysosomal-autophagic gene network in cultured cells: A call for caution. Autophagy. 201814(3):437-449.