1112169-64-8
1112169-64-8 structure
- Name: PF-152
- Chemical Name: N-(4-Fluoro-3-methoxybenzyl)-6-(2-{[(2S,5R)-5-(hydroxymethyl)-1,4 -dioxan-2-yl]methyl}-2H-tetrazol-5-yl)-2-methyl-4-pyrimidinecarbo xamide
- CAS Number: 1112169-64-8
- Molecular Formula: C21H24FN7O5
- Molecular Weight: 473.45800
- Create Date: 2016-11-04 20:15:19
- Modify Date: 2024-01-11 20:42:05
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PF-152 is a potent, highly selective and orally bioavailable MMP13 inhibitor with Ki of 1.5 nM, with no activity against MMP3 (Ki>10 uM).
| Name | N-(4-Fluoro-3-methoxybenzyl)-6-(2-{[(2S,5R)-5-(hydroxymethyl)-1,4 -dioxan-2-yl]methyl}-2H-tetrazol-5-yl)-2-methyl-4-pyrimidinecarbo xamide |
|---|---|
| Synonyms | PF-152 |
| Molecular Formula | C21H24FN7O5 |
|---|---|
| Molecular Weight | 473.45800 |
| Exact Mass | 473.18200 |
| PSA | 146.40000 |
| LogP | 0.68340 |
|
~25%
1112169-64-8 |
| Literature: PFIZER INC. Patent: WO2009/16498 A1, 2009 ; Location in patent: Page/Page column 152-153 ; WO 2009/016498 A1 |
| Precursor 2 | |
|---|---|
| DownStream 0 | |