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  • BioBioPha
  • China
  • Product Name: Enniatin B1
  • Price: ¥4650.0/5mg
  • Purity: 97.0%
  • Stocking Period: 10 Day
  • Contact: Xueping-Zheng

19914-20-6

19914-20-6 structure
19914-20-6 structure
  • Name: Enniatin B1
  • Chemical Name: Enniatin B1
  • CAS Number: 19914-20-6
  • Molecular Formula: C34H59N3O9
  • Molecular Weight: 653.847
  • Catalog: Natural product Alkaloid
  • Create Date: 2018-06-13 14:07:16
  • Modify Date: 2024-01-13 17:06:22
  • Enniatin B1 is a Fusarium mycotoxin. Enniatin B1 inhibits acyl-CoA: cholesterol acyltransferase (ACAT) activity with an IC50 of 73 μM in an enzyme assay using rat liver microsomes[1]. Enniatin B1 crosss the blood-brain barrier[2]. Enniatin B1 decreases the activation of ERK (p44/p42). Enniatin B1 inhibits moderately TNF-α-induced NF-κB activation[3].

Name Enniatin B1
Synonyms 1,7,13-Trioxa-4,10,16-triazacyclooctadecane-2,5,8,11,14,17-hexone, 4,10,16-trimethyl-3,6,9,12,18-pentakis(1-methylethyl)-15-[(1R)-1-methylpropyl]-, (3S,6R,9S,12R,15R,18R)-
1,7,13-Trioxa-4,10,16-triazacyclooctadecane-2,5,8,11,14,17-hexone, 4,10,16-trimethyl-3,6,9,12,18-pentakis(1-methylethyl)-15-[(1S)-1-methylpropyl]-, (3S,6R,9S,12R,15S,18R)-
(3R,6R,9S,12R,15S,18R)-3-[(2R)-2-Butanyl]-6,9,12,15,18-pentaisopropyl-4,10,16-trimethyl-1,7,13-trioxa-4,10,16-triazacyclooctadecane-2,5,8,11,14,17-hexone
(3S,6R,9S,12R,15S,18R)-3-[(2S)-2-Butanyl]-6,9,12,15,18-pentaisopropyl-4,10,16-trimethyl-1,7,13-trioxa-4,10,16-triazacyclooctadecane-2,5,8,11,14,17-hexone
Description Enniatin B1 is a Fusarium mycotoxin. Enniatin B1 inhibits acyl-CoA: cholesterol acyltransferase (ACAT) activity with an IC50 of 73 μM in an enzyme assay using rat liver microsomes[1]. Enniatin B1 crosss the blood-brain barrier[2]. Enniatin B1 decreases the activation of ERK (p44/p42). Enniatin B1 inhibits moderately TNF-α-induced NF-κB activation[3].
Related Catalog
Target

ACAT

ERK

NF-κB

In Vitro CCF-STTG1 cells are sensitive to Enniatin B1 (IC50=4.4 μM)[2].
References

[1]. Tomoda H, et al. Inhibition of acyl-CoA: cholesterol acyltransferase activity by cyclodepsipeptide antibiotics. J Antibiot (Tokyo). 1992 Oct;45(10):1626-32.

[2]. Krug I, et al. Transport of enniatin B and enniatin B1 across the blood-brain barrier and hints for neurotoxic effects in cerebral cells. PLoS One. 2018 May 16;13(5):e0197406.

[3]. Wätjen W, et al. Enniatins A1, B and B1 from an endophytic strain of Fusarium tricinctum induce apoptotic cell death in H4IIE hepatoma cells accompanied by inhibition of ERK phosphorylation. Mol Nutr Food Res. 2009 Apr;53(4):431-40.

Density 1.0±0.1 g/cm3
Boiling Point 833.8±65.0 °C at 760 mmHg
Molecular Formula C34H59N3O9
Molecular Weight 653.847
Flash Point 458.0±34.3 °C
Exact Mass 653.425110
PSA 139.83000
LogP 3.58
Vapour Pressure 0.0±3.1 mmHg at 25°C
Index of Refraction 1.460
Storage condition ?20°C
Water Solubility DMSO: soluble10mg/mL
Symbol GHS06
GHS06
Signal Word Danger
Hazard Statements H301-H311-H331
Precautionary Statements P261-P280-P301 + P310-P311
Hazard Codes T
Risk Phrases 23/24/25
Safety Phrases 45
RIDADR 2811
Packaging Group I