Enniatin B1

Modify Date: 2024-01-13 17:06:22

Enniatin B1 structure	Common Name	Enniatin B1
	CAS Number	19914-20-6	Molecular Weight	653.847
	Density	1.0±0.1 g/cm3	Boiling Point	833.8±65.0 °C at 760 mmHg
	Molecular Formula	C₃₄H₅₉N₃O₉	Melting Point	N/A
	MSDS	Chinese USA	Flash Point	458.0±34.3 °C
	Symbol	GHS06	Signal Word	Danger

Use of Enniatin B1

Enniatin B1 is a Fusarium mycotoxin. Enniatin B1 inhibits acyl-CoA: cholesterol acyltransferase (ACAT) activity with an IC50 of 73 μM in an enzyme assay using rat liver microsomes[1]. Enniatin B1 crosss the blood-brain barrier[2]. Enniatin B1 decreases the activation of ERK (p44/p42). Enniatin B1 inhibits moderately TNF-α-induced NF-κB activation[3].

Name	Enniatin B1
Synonym	More Synonyms

Description	Enniatin B1 is a Fusarium mycotoxin. Enniatin B1 inhibits acyl-CoA: cholesterol acyltransferase (ACAT) activity with an IC50 of 73 μM in an enzyme assay using rat liver microsomes[1]. Enniatin B1 crosss the blood-brain barrier[2]. Enniatin B1 decreases the activation of ERK (p44/p42). Enniatin B1 inhibits moderately TNF-α-induced NF-κB activation[3].
Related Catalog	Research Areas >> Cancer Research Areas >> Cardiovascular Disease Research Areas >> Infection Signaling Pathways >> MAPK/ERK Pathway >> ERK Signaling Pathways >> Metabolic Enzyme/Protease >> Acyltransferase Signaling Pathways >> Stem Cell/Wnt >> ERK
Target	ACAT ERK NF-κB
In Vitro	CCF-STTG1 cells are sensitive to Enniatin B1 (IC50=4.4 μM)[2].
References	[1]. Tomoda H, et al. Inhibition of acyl-CoA: cholesterol acyltransferase activity by cyclodepsipeptide antibiotics. J Antibiot (Tokyo). 1992 Oct;45(10):1626-32. [2]. Krug I, et al. Transport of enniatin B and enniatin B1 across the blood-brain barrier and hints for neurotoxic effects in cerebral cells. PLoS One. 2018 May 16;13(5):e0197406. [3]. Wätjen W, et al. Enniatins A1, B and B1 from an endophytic strain of Fusarium tricinctum induce apoptotic cell death in H4IIE hepatoma cells accompanied by inhibition of ERK phosphorylation. Mol Nutr Food Res. 2009 Apr;53(4):431-40.

Density	1.0±0.1 g/cm3
Boiling Point	833.8±65.0 °C at 760 mmHg
Molecular Formula	C₃₄H₅₉N₃O₉
Molecular Weight	653.847
Flash Point	458.0±34.3 °C
Exact Mass	653.425110
PSA	139.83000
LogP	3.58
Vapour Pressure	0.0±3.1 mmHg at 25°C
Index of Refraction	1.460
Storage condition	?20°C
Water Solubility	DMSO: soluble10mg/mL

Symbol	GHS06
Signal Word	Danger
Hazard Statements	H301-H311-H331
Precautionary Statements	P261-P280-P301 + P310-P311
Hazard Codes	T
Risk Phrases	23/24/25
Safety Phrases	45
RIDADR	2811
Packaging Group	I

1,7,13-Trioxa-4,10,16-triazacyclooctadecane-2,5,8,11,14,17-hexone, 4,10,16-trimethyl-3,6,9,12,18-pentakis(1-methylethyl)-15-[(1R)-1-methylpropyl]-, (3S,6R,9S,12R,15R,18R)-

1,7,13-Trioxa-4,10,16-triazacyclooctadecane-2,5,8,11,14,17-hexone, 4,10,16-trimethyl-3,6,9,12,18-pentakis(1-methylethyl)-15-[(1S)-1-methylpropyl]-, (3S,6R,9S,12R,15S,18R)-

(3R,6R,9S,12R,15S,18R)-3-[(2R)-2-Butanyl]-6,9,12,15,18-pentaisopropyl-4,10,16-trimethyl-1,7,13-trioxa-4,10,16-triazacyclooctadecane-2,5,8,11,14,17-hexone

(3S,6R,9S,12R,15S,18R)-3-[(2S)-2-Butanyl]-6,9,12,15,18-pentaisopropyl-4,10,16-trimethyl-1,7,13-trioxa-4,10,16-triazacyclooctadecane-2,5,8,11,14,17-hexone

Shanghai Nianxing Industrial Co., Ltd
China
Product Name: Enniatin B1
Price: Click To Check
Purity: 98.0%
Delivery: 10 Day
Contact: Yang
Email: sales@echemcloud.com

BioBioPha
China
Product Name: Enniatin B1
Price: ￥4650.0/5mg
Purity: 97.0%
Delivery: 10 Day
Contact: Xueping-Zheng
Email: 1477035482@qq.com

Shanghai Jizhi Biochemical Technology Co., Ltd
China
Product Name: Enniatin B1
Price: ￥5120.0/5mg
Purity: 98.0%
Delivery: 3 Day
Contact: Liu jia
Email: 2130147988@qq.com

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