Shanghai Nianxing Industrial Co., Ltd
China
Product Name: Neohesperidin
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Purity: 98.0%
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BioBioPha
China
Product Name: Neohesperidin
Price: ￥Inquiry/5mg
Purity: 98.0%
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Shanghai Jizhi Biochemical Technology Co., Ltd
China
Product Name: Neohesperidin
Price: ￥198.0/20mg
Purity: 98.0%
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DC Chemicals Limited
China
Product Name: Neohesperidin
Price: $280.0/20mg
Purity: 98.0%
Stocking Period: 3 Day
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Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: Neohesperidin
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
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13241-33-3

13241-33-3 structure

13241-33-3 structure

Name: Neohesperidin
Chemical Name: neohesperidin
CAS Number: 13241-33-3
Molecular Formula: C₂₈H₃₄O₁₅
Molecular Weight: 610.561
Catalog: Biochemical Chinese herbal medicine ingredients
Create Date: 2018-04-29 08:00:00
Modify Date: 2024-01-02 17:50:22
Neohesperidin is a flavonoid compound found in high amounts in Poncirus trifoliata with anti-oxidant and anti-inflammatory effects.

Name	neohesperidin
Synonyms	HESPERETIN-7-NEOHESPERIDOSIDE Hesperetin7-neohesperidoside 4H-1-Benzopyran-4-one, 7-[[2-O-(6-deoxy-α-L-mannopyranosyl)-β-D-glucopyranosyl]oxy]-2,3-dihydro-5-hydroxy-2-(3-hydroxy-4-methoxyphenyl)-, (2S)- (2S)-5-Hydroxy-2-(3-hydroxy-4-methoxyphenyl)-4-oxo-3,4-dihydro-2H-chromen-7-yl 2-O-(6-deoxy-α-L-mannopyranosyl)-β-D-glucopyranoside hesperetin 7-O-neohesperoside Neohesperidin Neohesperdin MFCD00017357 Hesperetin-7-O-neohesperidoside EINECS 236-216-9 (S)-4'-Methoxy-3',5,7-trihydroxyflavanone-7-[2-O-(α-L-rhamnopyranosyl)-β-D-glucopyranoside] 4H-1-Benzopyran-4-one, 2,3-dihydro-7-((2-O-(6-deoxy-α-L-mannopyranosyl)-β-D-glucopyranosyl)oxy)-5-hydroxy-2-(3-hydroxy-4-methoxyphenyl)-, (S)- Hesperetin 7-O-neohesperidoside

Description	Neohesperidin is a flavonoid compound found in high amounts in Poncirus trifoliata with anti-oxidant and anti-inflammatory effects.
Related Catalog	Signaling Pathways >> Others >> Others Research Areas >> Inflammation/Immunology Natural Products >> Flavonoids
In Vitro	Neohesperidin induces cell apoptosis in human breast adenocarcinoma MDA-MB-231 cells. The IC50 values of neohesperidin at 24 and 48 h are 47.4±2.6 μM and 32.5±1.8 μM, respectively. The expressions of P53 and Bax in the neohesperidin-treated cells are significantly up-regulated, while that of Bcl-2 is down-regulated[1]. Neohesperidin exhibits antioxidant activity (IC50=22.31 μg/mL) in the DPPH radical-scavenging assay[2].
In Vivo	Neohesperidin (50 mg/kg) significantly inhibits 55.0% of HCl/ethanol-induced gastric lesions. In pylorus ligated rats, neohesperidin (50 mg/kg) significantly decreases the volume of gastric secretion and gastric acid output, and increases the pH[1]. Treatment of neohesperidin significantly decreases fasting glucose, serum glucose, and glycosylated serum protein (GSP) in mice. It significantly elevates oral glucose tolerance and insulin sensitivity and decreases insulin resistance in the diabetic mice. Neohesperidin significantly decreases serum triglycerides, total cholesterol, leptin level, and liver index in the mice[3].
Animal Admin	Mice: All the mice are fasted 6 h before the test and then fed with water or neohesperidin by gavage. The mice are intraperitoneally injected with either 2 g/kg BW glucose or 1 IU/kg BW insulin for OGTT and ITT, respectively. Blood samples are collected from the tail vein for the measurement of basal blood glucose levels (0 min) before the injection of glucose or insulin. Additional blood glucose levels are measured at 30, 60, 90 and 120 min[3].
References	[1]. Lee JH, et al. Protective effects of neohesperidin and poncirin isolated from the fruits of Poncirus trifoliata on potential gastric disease. Phytother Res. 2009 Dec;23(12):1748-53. [2]. Xu F, et al. Neohesperidin induces cellular apoptosis in human breast adenocarcinoma MDA-MB-231 cells via activating the Bcl-2/Bax-mediated signaling pathway. Nat Prod Commun. 2012 Nov;7(11):1475-8. [3]. Jia S, et al. Hypoglycemic and hypolipidemic effects of neohesperidin derived from Citrus aurantium L. in diabetic KK-A(y) mice. Food Funct. 2015 Mar;6(3):878-86.

Density	1.7±0.1 g/cm3
Boiling Point	933.7±65.0 °C at 760 mmHg
Melting Point	239-243ºC
Molecular Formula	C₂₈H₃₄O₁₅
Molecular Weight	610.561
Flash Point	306.7±27.8 °C
Exact Mass	610.189758
PSA	234.29000
LogP	2.44
Vapour Pressure	0.0±0.3 mmHg at 25°C
Index of Refraction	1.695
Storage condition	2-8°C

CHEMICAL IDENTIFICATION

RTECS NUMBER :: DJ2981400

CHEMICAL NAME :: 4H-1-Benzopyran-4-one, 2,3-dihydro-7-((2-O-(6-deoxy-alpha-L-mannopyranosyl)- beta-D- glucopyranosyl)oxy)-5-hydroxy-2-(3-hydroxy-4-methoxyp henyl)-, (S)-

CAS REGISTRY NUMBER :: 13241-33-3

BEILSTEIN REFERENCE NO. :: 0074945

LAST UPDATED :: 199612

DATA ITEMS CITED :: 1

MOLECULAR FORMULA :: C28-H34-O15

MOLECULAR WEIGHT :: 610.62

Personal Protective Equipment	Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
Hazard Codes	Xn
Safety Phrases	S22-S24/25
RIDADR	NONH for all modes of transport
WGK Germany	3
RTECS	DJ2981400

Precursor 0
DownStream 1
38665-01-9